HIV integrase: A target for AIDS therapeutics

被引：39
|
作者：
Thomas, M
Brady, L
机构：
[1] Department of Biochemistry, University of Bristol, Bristol
来源：
TRENDS IN BIOTECHNOLOGY | 1997年 / 15卷 / 05期
关键词：
D O I：
10.1016/S0167-7799(97)01016-0
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
HIV integrase catalyses the incorporation of virally derived DNA into the human genome. This unique step in the virus life cycle provides a variety of points for intervention and hence is an attractive target for the development of new therapeutics for the treatment of AIDS. In this review we summarize current knowledge of the function of this enzyme and discuss some of the obstacles to the development of appropriate drugs.
引用
收藏
页码：167 / 172
页数：6
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