p21Waf1/Cip1 as a molecular sensor for BoHV-4 replication

被引：3

作者：

Capocefalo, A. ^{[1
]}

Franceschi, V. ^{[1
]}

Whitelaw, C. B. A. ^{[2
,3
]}

Vasey, D. B. ^{[2
,3
]}

Lillico, S. G. ^{[2
,3
]}

Cavirani, S. ^{[1
]}

Donofrio, G. ^{[1
]}

机构：

[1] Fac Med Vet, Dipartimento Salute Anim, Sez Malattie Infett Anim, I-43100 Parma, Italy

[2] Univ Edinburgh, Div Dev Biol, Roslin Inst, Roslin EH25 9PS, Midlothian, Scotland

[3] Univ Edinburgh, Royal Dick Sch Vet Studies, Roslin EH25 9PS, Midlothian, Scotland

来源：

JOURNAL OF VIROLOGICAL METHODS | 2009年 / 161卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

BoHV-4; p21(Waf1/Cip1); Cellular damage; CYCLIN-DEPENDENT KINASES; BOVINE HERPESVIRUS-4; DNA-DAMAGE; P21; IDENTIFICATION; INHIBITION; VIRUS; P53;

D O I：

10.1016/j.jviromet.2009.06.012

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

BoHV-4 replication cycle is dependent on the S-phase of the cell-cycle at the stage of viral DNA synthesis. Because p21 is a rate-limiting regulator of the G1/S-phase transition and up-regulated by DNA-damaging agents, in this study p21 expression in BoHV-4 infected cells was investigated. The p21 promoter was found to be highly activated in a dose- and time-dependent manner following BoHV-4 infection only in cells which are permissive for BoHV-4 replication. Thus p21 expression reports on BoHV-4 replication and could represent a host cell defensive response to infection-associated cellular damage. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：308 / 311

页数：4

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