Asymmetric hydrogenation of cyclic alpha,beta-unsaturated ketones to chiral allylic alcohols

被引：0
|
作者：
Ohkuma, T [1 ]
Ikehira, H [1 ]
Ikariya, T [1 ]
Noyori, R [1 ]
机构：
[1] RES DEV CORP JAPAN, ERATO, MOL CATALYSIS PROJECT, TOYOTA 47003, JAPAN
来源：
SYNLETT | 1997年 / 05期
关键词：
asymmetric hydrogenation; BINAP; chiral allylic alcohol; chiral 1,2-diamine; alpha; beta-unsaturated ketone;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Ru(II)-BINAP-1,2-diphenylethylenediamine combined catalyst system effects asymmetric hydrogenation of certain cyclic enones in 2-propanol containing KOH with a substrate/catalyst molar ratio of 250 to 2500. The hydrogenation occurs selectively at the C=O function with excellent enantio- or diastereoselectivity.
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页码：467 / +
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