Host resistance to Listeria monocytogenes infection is enhanced but resistance to Staphylococcus aureus infection is reduced in acute graft-versus-host disease in mice

被引:5
|
作者
Miura, T
Mizuki, D
Sasaki, S
Hasegawa, S
Sashinami, H
Nakane, A
机构
[1] Hirosaki Univ, Sch Med, Dept Bacteriol, Hirosaki, Aomori 0368562, Japan
[2] Hirosaki Univ, Sch Allied Med Sci, Hirosaki, Aomori, Japan
关键词
D O I
10.1128/IAI.68.7.4340-4343.2000
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Acute graft-versus-host disease (GVHD) is characterized by the production of high levels of T helper 1 (Th1)-type cytokines. Bone marrow transplantation from allogeneic C57BL/6 cells to CBF1 mice produced acute GVHD. Host resistance to Th2-driven Listeria monocytogenes was enhanced, whereas host resistance to Th2-driven Staphylococcus aureus was reduced during acute GVHD. These results suggest that opposite host responses are observed between Th1-driven and Th2-driven bacterial infections in acute GVHD.
引用
收藏
页码:4340 / 4343
页数:4
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