Age-related gene expression and DNA methylation changes in rhesus macaque

被引：14

作者：

Zhou, Min ^{[1
]}

Zhang, Liang ^{[2
]}

Yang, Qiao ^{[1
]}

Yan, Chaochao ^{[1
]}

Jiang, Peng ^{[3
]}

Lan, Yue ^{[1
]}

Wang, Jiao ^{[1
]}

Tang, Ruixiang ^{[1
]}

He, Miao ^{[3
]}

Lei, Guanglun ^{[4
]}

Sun, Pan ^{[3
]}

Su, Na ^{[3
]}

Price, Megan ^{[1
]}

Li, Jing ^{[1
]}

Lin, Fangzhao ^{[3
]}

Yue, Bisong ^{[1
]}

Fan, Zhenxin ^{[1
]}

机构：

[1] Sichuan Univ, Coll Life Sci, Key Lab Bioresources & Ecoenvironm, Minist Educ, Chengdu 610065, Sichuan, Peoples R China

[2] Chengdu Res Base Giant Panda Breeding, Sichuan Key Lab Conservat Biol Endangered Wildlif, Chengdu 610081, Sichuan, Peoples R China

[3] Chinese Acad Med Sci, Inst Blood Transfus, Chengdu 610052, Sichuan, Peoples R China

[4] Sichuan Green House Biotech Co Ltd, Meishan 620010, Sichuan, Peoples R China

来源：

GENOMICS | 2020年 / 112卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Rhesus macaque; Gene expression; DNA methylation; Blood coagulation; Aging; LIFE-SPAN; EVOLUTIONARY; DEFICIENCY; PROFILES; IMPACT; WILD;

D O I：

10.1016/j.ygeno.2020.09.021

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aging is a very complicated biological process that can change gene expressions. The Chinese rhesus macaque (Macaca mulatta lasiota; CR) is closely related to humans. We explored gene expression with increasing age and DNA methylation changes in young and old CRs. Results showed blood transcriptome and DNA methylome significantly changed from young to old CRs. The age-associated differentially expressed genes (DEGs) and differentially methylated regions (DMRs) were associated with age-related biological features, such as immunity, blood coagulation, and biosynthetic process. The measurements of coagulation indicators confirmed old CRs had shorter coagulation time than young CRs, and the activities of coagulation factor II (FII) and factor VIII (FVIII) were enhanced in old CRs. Humans and CRs exhibited the same enhanced blood coagulation with age phenotype. Our study found aging is a critical factor affecting gene expression in CRs, and also provided new insights into the blood coagulation changes in non-human primates.

引用

页码：5147 / 5156

页数：10

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