Getting a "Hold" on NPC2

被引：3
|
作者：
Ory, Daniel S. [1 ,2 ]
机构：
[1] Washington Univ, Sch Med, Dept Med & Cell Biol, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Physiol, St Louis, MO 63110 USA
来源：
CELL METABOLISM | 2009年 / 10卷 / 03期
关键词：
PICK-C DISEASE; CHOLESTEROL; IDENTIFICATION; PROTEIN; NOGO;
D O I：
10.1016/j.cmet.2009.08.006
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Lipoprotein cholesterol is mobilized from lysosomes by actions of the NPC1 and NPC2 proteins. In this issue of Cell Metabolism, Harrison et al. report on identification of an NPC2-interacting protein, the Nogo-B receptor, that regulates NPC2 protein levels. NPC2 stabilization may represent a novel mechanism through which cells respond to endocytosed cholesterol.
引用
收藏
页码：161 / 162
页数：2
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