Use of the triflamide group for Friedel-crafts acylation of N-(beta-phenethyl)amino acids to 3-benzazepine derivatives

被引：19
|
作者：
Kawase, M
Motohashi, N
Niwa, M
Nozaki, M
机构：
[1] MEIJI COLL PHARM,TANASHI,TOKYO 188,JAPAN
[2] GIFU UNIV,SCH MED,GIFU 500,JAPAN
[3] RES INST PROD DEV,SAKYO KU,KYOTO 606,JAPAN
来源：
HETEROCYCLES | 1997年 / 45卷 / 06期
关键词：
D O I：
10.3987/COM-97-7803
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Triflamides of N-(beta-phenethyl)amino acids (1) were treated with P2O5 under the Friedel-Crafts acylation conditions to give the 3-benzazepines in good yields. N-(beta-Phenethyl)-N-triflylvaline (If) and phenylglycine (1g) were efficiently prepared from the corresponding N-triflylamino acids and beta-phenethyl alcohol via the Mitsunobu reaction.
引用
收藏
页码：1121 / 1129
页数：9
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