ACY-241, a Novel, HDAC6 Selective Inhibitor: Synergy with Immunomodulatory (IMiD®) Drugs in Multiple Myeloma (MM) Cells and Early Clinical Results (ACE-MM-200 Study)

被引:0
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作者
Niesvizky, Ruben [1 ]
Richardson, Paul G. [2 ]
Gabrail, Nashat Y. [3 ]
Madan, Sumit [4 ]
Yee, Andrew J. [5 ]
Quayle, Steven N. [6 ]
Almeciga-Pinto, Ingrid [6 ]
Jones, Simon S. [6 ]
Houston, Lee [6 ]
Hayes, Denise [6 ]
Van Duzer, John [6 ]
Wheeler, Catherine [6 ]
Trede, Nikolaus S. [6 ]
Raje, Noopur S. [5 ]
机构
[1] Weill Cornell Med Coll, Ctr Excellence Lymphoma & Myeloma, New York, NY USA
[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Malignancy,Dept Med Oncol,Jerome Lipp, Boston, MA 02115 USA
[3] Gabrail Canc Ctr, Canton, OH USA
[4] Univ Texas Hlth Sci Ctr San Antonio, Canc Therapy & Res Ctr, Hematol Oncol, San Antonio, TX 78229 USA
[5] Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA
[6] Acetylon Pharmaceut Inc, Boston, MA USA
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中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
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页数:3
相关论文
共 16 条
  • [1] ACY-241, A NOVEL, ORAL TABLET HDAC6 SELECTIVE INHIBITOR COMBINES SAFELY WITH POMALIDOMIDE AND DEXAMETHASONE IN PATIENTS WITH RELAPSED OR RELAPSED AND REFRACTORY MULTIPLE MYELOMA (ACE-MM-200 STUDY)
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    Terpos, E.
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    HAEMATOLOGICA, 2016, 101 : 524 - 525
  • [2] Selective HDAC inhibition by ricolinostat (ACY-1215) or ACY-241 synergizes with IMiD® immunomodulatory drugs in Multiple Myeloma (MM) and Mantle Cell Lymphoma (MCL) cells
    Quayle, Steven N.
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    Jones, Simon S.
    CANCER RESEARCH, 2015, 75
  • [3] Selective HDAC6 Inhibitor ACY-241, an Oral Tablet, Combined with Pomalidomide and Dexamethasone: Safety and Efficacy of Escalation and Expansion Cohorts in Patients with Relapsed or Relapsed-and-Refractory Multiple Myeloma (ACE-MM-200 Study)
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    Yee, Andrew J.
    Nooka, Ajay K.
    Raab, Marc S.
    Shain, Kenneth H.
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    Pagel, John M.
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    BLOOD, 2016, 128 (22)
  • [4] ACY-1215, a selective inhibitor of HDAC6, synergizes with immunomodulatory drugs (IMiDs) to induce apoptosis of multiple myeloma (MM) cells
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  • [5] ACY-1215, a First-In-Class Selective Inhibitor Of HDAC6, Demonstrates Significant Synergy With Immunomodulatory Drugs (IMiDs) In Preclinical Models Of Multiple Myeloma (MM)
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  • [6] Selective Inhibition of HDAC6 with a New Prototype Inhibitor (ACY-1215) Overcomes Bortezomib Resistance In Multiple Myeloma (MM)
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  • [7] Combination of a novel HDAC6 inhibitor ACY-241 and anti-PD-L1 antibody enhances anti-tumor immunity and cytotoxicity in multiple myeloma
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    LEUKEMIA, 2018, 32 (03) : 843 - 846
  • [9] Ricolinostat (ACY-1215), the First Selective HDAC6 Inhibitor, Combines Safely with Pomalidomide and Dexamethasone and Shows Promosing Early Results in Relapsed-and-Refractory Myeloma (ACE-MM-102 Study)
    Raje, Noopur S.
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  • [10] Ricolinostat (ACY-1215), the First Selective HDAC6 Inhibitor, in Combonation with Lenalidomide and Dexamethasone in Patients with Relapsed and Relapsed -and Refractory Multiple Myeloma: Phase lb Results (ACE-MM-101 Study)
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