A highly selective fluorescent probe for hydrogen peroxide and its applications in living cells

被引：12
|
作者：
Zhuang, Zhiyuan [1 ]
Yang, Qian [1 ]
Zhang, Zhanming [1 ]
Zhang, Qilong [1 ]
Zheng, Gengxiu [1 ]
Zhan, Fuxu [1 ]
机构：
[1] Univ Jinan, Sch Chem & Chem Engn, Jinan 250022, Shandong, Peoples R China
来源：
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY | 2017年 / 344卷
基金：
美国国家科学基金会;
关键词：
Hydrogen peroxide; Selective detection; Fluorescent probe; TURN-ON; OXIDATIVE STRESS; REACTIVE OXYGEN; H2O2; MITOCHONDRIA; OXIDANTS; SIGNALS;
D O I：
10.1016/j.jPhotochem.2017.04.009
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A turn-on fluorescent probe ACR {6 '-[2-(azidomethyl)benzoy1]-7 '-chloro-N,N-diethylrhodol} for selective detection of H2O2 was developed. An ester bond was broken by the nucleophilic substitution of H2O2 which released strong fluorescence. Probe ACR was proved to be made up" of three essential parts, chlorine atom, azide group and an active carbonyl. This probe showed high selectivity for H2O2 and a linear fluorescence intensity enhancement with a wide range of concentrations of H2O2. Fluorescence imaging experiments in HeLa cells indicated its potential to image H2O2 in biological systems. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：8 / 14
页数：7
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