Zirconium(IV) chloride as versatile catalyst for the expeditious synthesis of quinoxalines and pyrido[2,3-b]pyrazines under ambient conditions

被引：38

作者：

Aghapoor, Kioumars ^{[1
]}

Darabi, Hossein Reza ^{[1
]}

Mohsenzadeh, Farshid ^{[1
]}

Balavar, Yadollah ^{[1
]}

Daneshyar, Hesam ^{[1
]}

机构：

[1] Chem & Chem Engn Res Ctr Iran, Tehran 1496813151, Iran

来源：

TRANSITION METAL CHEMISTRY | 2010年 / 35卷 / 01期

关键词：

SOLVENT-FREE CONDITIONS; ROOM-TEMPERATURE; MICROWAVE IRRADIATION; RECEPTOR ANTAGONISTS; EFFICIENT SYNTHESIS; REUSABLE CATALYST; POWERFUL CATALYST; ORGANIC-SYNTHESIS; MOLECULAR-IODINE; MICHAEL ADDITION;

D O I：

10.1007/s11243-009-9294-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Among the various transition metal chlorides, zirconium(IV) chloride was found to be an efficient catalyst for the rapid synthesis of a wide range of 2,3-dialkyl- and 2,3-diaryl-quinoxaline and pyrido[2,3-b]pyrazine derivatives in excellent yields at room temperature. The remarkable features of this catalytic process are the mild reaction conditions, quantitative yields, short reaction times, high conversions, tolerability of various functional groups, clean reaction profiles, and operational simplicity. Among the various transition metal chlorides, zirconium(IV) chloride was found to be an efficient catalyst for the rapid synthesis of a wide range of 2,3-dialkyl- and 2,3-diaryl-quinoxaline and pyrido[2,3-b]pyrazine derivatives in excellent yields at room temperature. The remarkable features of this catalytic process are the mild reaction conditions, quantitative yields, short reaction times, high conversions, tolerability of various functional groups, clean reaction profiles, and operational simplicity.

引用

页码：49 / 53

页数：5

共 50 条

[1] Zirconium(IV) chloride as versatile catalyst for the expeditious synthesis of quinoxalines and pyrido[2,3-b]pyrazines under ambient conditions
Kioumars Aghapoor
Hossein Reza Darabi
Farshid Mohsenzadeh
Yadollah Balavar
Hesam Daneshyar
Transition Metal Chemistry, 2010, 35 : 49 - 53
[2] SYNTHESIS OF PYRIDO[2,3-B]QUINOXALINES
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[8] Synthesis of pyrido[2,3-b]pyrazines from pyrido[2,3-c]furoxan
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[10] ELECTROCHEMICAL REDUCTION OF PYRIDO 2,3-B PYRAZINES
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