Modulation of AML-blasts with clinically approved response modifiers to leukemia-derived dendritic cells (DCLEU) ex vivo: DC-, T-cell- and cytokine profiles are predictive for antileukemic T-cell reactivity

被引：0
|
作者：
Fischer, Zuzana [1 ]
Deen, Diana [1 ]
Hirn, Anika [1 ]
Plett, Caroline [1 ]
Kugler, Christoph [1 ]
Liepert, Anja [1 ]
Freudenreich, Markus [1 ]
Kraemer, Doris [2 ]
Schmid, Christoph [3 ]
Schmetzer, Helga Maria [1 ]
机构：
[1] Univ Hosp Munich Grosshadern, Munich, Germany
[2] Municipal Hosp Oldenburg, Oldenburg, Germany
[3] Municipal Hosp Augsburg, Augsburg, Germany
来源：
BONE MARROW TRANSPLANTATION | 2019年 / 54卷
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D O I：
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中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
P589
引用
收藏
页码：520 / 521
页数：2
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  • [1] Modulation of AML-blasts with clinically approved response modifiers to leukemia-derived dendritic cells (DCleu) ex vivo: DC-, T-cell- and cytokine profiles are predictive for antileukemic T-cell reactivity
    Fischer, Z.
    Deen, D.
    Hirn, A.
    Plett, C.
    Kugler, C.
    Rabe, A.
    Liepert, A.
    Freudenreich, M.
    Kraemer, D.
    Schmid, C.
    Schmetzer, H. M.
    [J]. EUROPEAN JOURNAL OF CANCER, 2019, 110 : S27 - S28
  • [2] Conversion of AML-blasts to leukemia-derived dendritic cells (DCleu) in 'DC-culture-media' shifts correlations of released chemokines with antileukemic T-cell reactions
    Merle, M.
    Fischbacher, D.
    Liepert, A.
    Grabrucker, C.
    Kroell, T.
    Kremser, A.
    Dreyssig, J.
    Freudenreich, M.
    Schuster, F.
    Borkhardt, A.
    Kraemer, D.
    Koehne, C-H
    Kolb, H. J.
    Schmid, C.
    Schmetzer, H. M.
    [J]. IMMUNOBIOLOGY, 2021, 226 (03)
  • [3] Immunemodulation of AML-blasts with clinically approved response modifiers improves antileukemic T-cell reactivity ex vivo and leads to blast-reduction in vivo (rat-model)
    Inngjerdingen, M.
    Rabe, A.
    Deen, D.
    Stankova, Z.
    Hirn, A.
    Vokac, Y.
    Wendtner, C.
    Tischer, J.
    Schmid, C.
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    [J]. EUROPEAN JOURNAL OF CANCER, 2016, 55 : S23 - S24
  • [4] Immunemodulation of AML-blasts with clinically approved response modifiers improves antileukemic T-cell reactivity ex vivo and leads to blast-reduction in vivo (rat-Modell)
    Inngjerdingen, M.
    Rabe, A.
    Deen, D.
    Stankova, Z.
    Hirn, A.
    Tischer, J.
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    [J]. BONE MARROW TRANSPLANTATION, 2016, 51 : S474 - S474
  • [5] IMMUNOMODULATION OF BLASTS IN AML-PATIENTS (AML-PTS) WITH CLINICALLY APPROVED RESPONSE MODIFIERS TO IMPROVE ANTILEUKEMIC T-CELL REACTIVITY: AN EX VIVO SIMULATION OF THE CLINICAL
    Helga, Schmetzer
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    Annika, Hirn-Lopez
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    [J]. EUROPEAN JOURNAL OF CANCER, 2015, 51 : S5 - S5
  • [6] Immunemodulation of blasts in AML-patients (pts) with clinically approved response modifiers to improve antileukemic T-cell reactivity: An ex vivo simulation of the clinical situation
    Schmetzer, H.
    Stankova, Z.
    Deen, D.
    Hirn-Lopez, A.
    Vokac, Y.
    Rabe, A.
    Stoschek, T.
    Kroelli, T.
    Wendtner, C.
    Schmid, C.
    Tischer, J.
    [J]. BONE MARROW TRANSPLANTATION, 2015, 50 : S123 - S123
  • [7] IMMUNMODULATION OF BLASTS IN AML-PATIENTS (PTS) WITH CLINICALLY APPROVED RESPONSE MODIFIERS TO IMPROVE ANTILEUKEMIC T-CELL REACTIVITY: AN EX VIVO SIMULATION OF THE CLINICAL SITUATION
    Schmetzer, H.
    Stankova, Z.
    Deen, D.
    Hirn, A.
    Vokac, Y.
    Kroell, T.
    Bund, D.
    Buhmann, R.
    Hausmann, A.
    Schmid, C.
    Tischer, J.
    [J]. BONE MARROW TRANSPLANTATION, 2014, 49 : S150 - S150
  • [8] Conversion of AML-blasts to leukemia-derived dendritic cells (DCleu) in 'DC-culture-media' shifts the (serum) chemokine-release profile to a more 'inflammatory' (in culture) going along with improved antileukemic T-cell-reactivity
    Merle, M.
    Fischbacher, D.
    Liepert, A.
    Grabrucker, C.
    Kroell, T.
    Kremser, A.
    Dreyssig, J.
    Freudenreich, M.
    Schuster, F.
    Borkhardt, A.
    Kraemer, D.
    Koehne, C.
    Kolb, H. J.
    Schmid, C.
    Schmetzer, H. M.
    [J]. EUROPEAN JOURNAL OF CANCER, 2019, 110 : S24 - S24
  • [9] AML-blast conversion to leukemia-derived dendritic cells (DCLEU) in 'DC-culture-media' shifts the (SERUM) chemokine-release to a more 'inflammatory' (in culture) going along with improved antileukemic T-cell-reactivity
    Merle, Marion
    Fischbacher, Dorothea
    Liepert, Anja
    Grabrucker, Christine
    Kroell, Tanja
    Kremser, Andreas
    Dreyssig, Julia
    Freudenreich, Markus
    Schuster, F.
    Borkhardt, A.
    Kraemer, D.
    Koehne, C. -H.
    Kolb, H. J.
    Schmid, C.
    Schmetzer, Helga Maria
    [J]. BONE MARROW TRANSPLANTATION, 2019, 54 : 187 - 187
  • [10] Role of IFNα in DC-cocktails for the generation of (leukemia-derived) dendritic cells from AML-blasts, the induction of antileukaemic functionality of DC-stimulated T-cells and in correlation with clinical response to immunotherapy
    Hirn-Lopez, A.
    Deen, D.
    Vokac, Y.
    Kroell, T.
    Kraemer, D.
    Schuster, F.
    Borkhardt, A.
    Schmid, C.
    Kolb, H. -J.
    Tischer, J.
    Schmetzer, H.
    [J]. BONE MARROW TRANSPLANTATION, 2013, 48 : S83 - S83
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