Optical monitoring of the meningeal lymphatic clearance after opening of blood-brain barrier

被引：0
|
作者：
Torres, Duarte E. N. [1 ]
Abdurashitov, A. S. [1 ,2 ]
Namykin, A. A. [2 ]
Shirokov, A. A. [1 ]
Shushunova, N. A. [1 ]
Khorovodov, A. P. [1 ]
Sarantsev, E., I [1 ]
Semyachkina-Glushkovskaya, O., V [1 ]
机构：
[1] Saratov State Univ NG Chernyshevsky, Interdisciplinary Ctr Crit Technol Med, Astrakhanskaya 83, Saratov 410012, Russia
[2] Saratov State Univ NG Chernyshevsky, Fac Phys, Dept Opt & Biophoton, Ul Astrakhanskaya 83, Saratov 410012, Russia
来源：
SARATOV FALL MEETING 2018: COMPUTATIONS AND DATA ANALYSIS: FROM NANOSCALE TOOLS TO BRAIN FUNCTIONS | 2019年 / 11067卷
基金：
俄罗斯科学基金会;
关键词：
blood-brain barrier; brain clearing; optical coherent tomography; fluorescence microscopy; SYSTEM; FLUID;
D O I：
10.1117/12.2524427
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In our experiments on rats we performed visualization of brain clearing from substances injected into the brain parenchyma using optical coherent tomography and fluorescence microscopy. Our results uncovered that the meningeal lymphatic system play an important role in the brain clearing processes, where the deep cervical lymph node is the first anatomical station of cerebral fluid exist from the brain. These data shed light on the novel mechanisms underlying drainage and clearing function of the brain.
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页数：5
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