Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms

被引：13

作者：

Carvalho, Valeria L. ^{[1
,2
]}

Long, Maureen T. ^{[1
]}

机构：

[1] Univ Florida, Coll Vet Med, Dept Comparat Diagnost & Populat Med, 1945 SW 16th Ave, Gainesville, FL 32608 USA

[2] Minist Hlth, Evandro Chagas Inst, Dept Arbovirol & Hemorrhag Fevers, Rodovia BR 316,Km 7,S-N, BR-67030000 Ananindeua, Para, Brazil

来源：

VACCINES | 2021年 / 9卷 / 03期

关键词：

vaccines; insect-specific virus; arbovirus; FLAVIVIRUS; INFECTION;

D O I：

10.3390/vaccines9030263

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Arthropod-borne viruses (arboviruses) are global pathogens circulating endemically with local explosive outbreaks and constant encroachment into new locations. Few vaccines against arboviruses exist; most for humans are in development or clinical trials. Insect-specific viruses (ISVs) offer a unique platform for expression of arbovirus proteins, through the creation of ISV/arbovirus chimeras. Studies have shown promising results of these vaccines with several advantages over their wild-type counterparts. In this review, we discuss the current status of these potential vaccines using ISVs.

引用

页数：9

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