Inhibition of the DNA damage response to activate immune responses toward tumors

被引：0

作者：

Sharma, Sheetal ^{[1
]}

Srivastava, Mrinal ^{[2
]}

机构：

[1] Postgrad Inst Med Res & Educ, Dept Expt Med & Biotechnol, Chandigarh 160012, India

[2] Tata Inst Fundamental Res TIFR Hyderabad, TIFR Ctr Interdisciplinary Sci, Hyderabad 500046, Telangana, India

来源：

FEBS JOURNAL | 2021年 / 288卷 / 15期

关键词：

ATRi; Chk1i; DNA damage response; immunotherapy; innate immune response; Wee1i; SENESCENCE;

D O I：

10.1111/febs.15836

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer immunotherapy represents a very encouraging mode of treatment for cancer where one's immune system is utilized to eliminate tumor cells. Wayne et al. explore inhibition of DNA damage response (DDR) pathways with small molecule inhibitors as a means to prime cells with immune response. These findings suggest that a one-size-fits-all approach cannot be used when harnessing immune response via DDR inhibitors and genotoxic agents, which are required ultimately for the success of immunotherapy.

引用

页码：4503 / 4506

页数：4

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