High-precision quantum transmittometry of DNA and methylene-blue using a frequency-entangled twin-photon beam in type-I SPDC

Using the coincidence-count (CC) measurement of the generated frequency-entangled twin-photon beam (TWB) via the process of type-I spontaneous parametric-down conversion (SPDC) in BBO nonlinear crystal (NLC), we have precisely measured the transmittance of very diluted rabbit- and human-DNA, methylene-blue (MB) as a disinfectant, and a thin-film multilayer at near IR wavelength 810nm with an accuracy in order of %0.01 due to the quantum correlation, while the accuracy of classical-like measurement, single-count (SC), is in order of %0.1 in our setup. Moreover, using quantum measurement of the transmittance, the different types of DNA with the same concentration, and also very diluted (in order of pg/mu l) different concentrations of DNA and MB solutions, are distinguished and detected with high-reliability. Interestingly, in the case of human-DNA samples in contrast to our classical-like measurement, we could precisely detect and distinguish two very diluted concentrations 0.01ng/mu l and 0.1ng/mu l with high reliability while the commercial standard spectrometer device of our DNA-manufacturer could neither detect nor distinguish them. Surprisingly, measurement on the thin-film multilayer illustrates that the introduced method in this work might be performed to cancer/brain tissues or stem cells for cancer therapy and may hopefully open a pave and platform for non-invasive quantum diagnosis in the future. (C) 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement