The Successful Treatment of Myeloperoxidase Antineutrophil Cytoplasmic Antibody-positive Hypertrophic Pachymeningitis in Patients with the Limited Form of Granulomatosis with Polyangiitis Using Methotrexate: Two Case Reports

被引：2
|
作者：
Kaieda, Shinjiro [1 ]
Yoshida, Naomi [1 ]
Minezaki, Midori [1 ]
Ushijima, Shuri [1 ]
Wakasugi, Daisuke [1 ]
Miura, Shiroh [1 ]
Uchiyama, Yusuke [2 ]
Ida, Hiroaki [1 ]
Hoshino, Tomoaki [1 ]
机构：
[1] Kurume Univ, Sch Med, Div Respirol Neurol & Rheumatol, Dept Med, Kurume, Fukuoka, Japan
[2] Kurume Univ, Sch Med, Dept Radiol, Kurume, Fukuoka, Japan
来源：
INTERNAL MEDICINE | 2017年 / 56卷 / 08期
关键词：
granulomatosis with polyangiitis; hypertrophic pachymeningitis; methotrexate (MTX); MPO-ANCA; WEGENERS-GRANULOMATOSIS; CRANIAL PACHYMENINGITIS; RANDOMIZED-TRIAL; VASCULITIS; CYCLOPHOSPHAMIDE; CLASSIFICATION; RITUXIMAB; DISEASE;
D O I：
10.2169/internalmedicine.56.7742
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recent findings have indicated a close relationship between myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-positive hypertrophic pachymeningitis and the limited form of granulomatosis with polyangiitis (GPA). In Japan, MPO-ANCA-positive hypertrophic pachymeningitis predominantly occurs in elderly individuals. We herein describe the cases of two patients with MPO-ANCA-positive hypertrophic pachymeningitis associated with the limited form of GPA who were successfully treated with a combination of corticosteroids and methotrexate. Although methotrexate has been shown to be less effective than cyclophosphamide for inducing the remission of GPA in patients with organ-threatening diseases, its safety and efficacy may make it a useful alternative treatment modality for patients with the limited form of GPA who show meningeal involvement.
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收藏
页码：959 / 965
页数：7
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