The southern Apulia foreland recorded a strong (Imax=X MCS) earthquake in 1743 and a concomitant tsunami, which struck the southeastern Salento coast. The seismo-genetic fault and the triggering factors of the tsunami are unknown. Three-dimensional interpretation of multichannel seismic profiles calibrated by wells using a GIS software enabled the recognition of the stratigraphic succession, structural framework, and submarine landslides offshore Salento. A thin Pliocene unit overlying the Mesozoic-Cenozoic substrate is covered by a Pleistocene succession separated by a Middle Pleistocene unconformity that formed during the regional uplift of Salento. The latter gave rise to the morphologic conditions for the deposition of a prograding wedge off the Salento coast, with a shelf break located at 150 m depth. Normal faults, mainly oriented NW-SE, displaced the early Lower Pleistocene succession and are buried by younger deposits. Since the Middle Pleistocene, a compressional event gave rise to the Apulia uplift and large folds and basement-involved reverse faults that are active in the eastern part of Apulia. A huge (58 km(3)) slump affecting the Middle Pleistocene prograding wedge has been documented offshore the southeast coast of Salento. The proposed geological scenario of the 1743 earthquake and subsequent tsunami is (1) an initial strong earthquake (Imax=X MCS) associated with a thrust fault located in the eastern sector of the Apulia offshore, (2) a shacking-induced large-volume slump offshore Otranto, and (3) landslide-triggered tsunamis that struck the Salento coast.