Upregulation of Connexin 43 Expression Via C-Jun N-Terminal Kinase Signaling in Prion Disease
被引:5
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作者:
Lee, Geon-Hwi
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机构:
Hallym Univ, Ilsong Inst Life Sci, Anyang 431815, Gyeonggi Do, South Korea
Hallym Univ, Grad Sch, Dept Biomed Gerontol, Chunchon, Gangwon Do, South KoreaHallym Univ, Ilsong Inst Life Sci, Anyang 431815, Gyeonggi Do, South Korea
Lee, Geon-Hwi
[1
,2
]
Jang, Byungki
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Hallym Univ, Ilsong Inst Life Sci, Anyang 431815, Gyeonggi Do, South KoreaHallym Univ, Ilsong Inst Life Sci, Anyang 431815, Gyeonggi Do, South Korea
Jang, Byungki
[1
]
Choi, Hong-Seok
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机构:
Hallym Univ, Ilsong Inst Life Sci, Anyang 431815, Gyeonggi Do, South Korea
Hallym Univ, Coll Med, Dept Microbiol, Chunchon, Gangwon Do, South KoreaHallym Univ, Ilsong Inst Life Sci, Anyang 431815, Gyeonggi Do, South Korea
Choi, Hong-Seok
[1
,3
]
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机构:
Kim, Hee-Jun
[1
]
Park, Jeong-Ho
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机构:
Hallym Univ, Ilsong Inst Life Sci, Anyang 431815, Gyeonggi Do, South Korea
Hallym Univ, Coll Med, Dept Microbiol, Chunchon, Gangwon Do, South KoreaHallym Univ, Ilsong Inst Life Sci, Anyang 431815, Gyeonggi Do, South Korea
Park, Jeong-Ho
[1
,3
]
Jeon, Yong-Chul
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Hallym Univ, Ilsong Inst Life Sci, Anyang 431815, Gyeonggi Do, South KoreaHallym Univ, Ilsong Inst Life Sci, Anyang 431815, Gyeonggi Do, South Korea
Jeon, Yong-Chul
[1
]
Carp, Richard I.
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机构:
New York State Inst Basic Res Dev Disabil, Staten Isl, NY 10314 USAHallym Univ, Ilsong Inst Life Sci, Anyang 431815, Gyeonggi Do, South Korea
Carp, Richard I.
[4
]
Kim, Yong-Sun
论文数: 0引用数: 0
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机构:
Hallym Univ, Ilsong Inst Life Sci, Anyang 431815, Gyeonggi Do, South Korea
Hallym Univ, Coll Med, Dept Microbiol, Chunchon, Gangwon Do, South KoreaHallym Univ, Ilsong Inst Life Sci, Anyang 431815, Gyeonggi Do, South Korea
Kim, Yong-Sun
[1
,3
]
Choi, Eun-Kyoung
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机构:
Hallym Univ, Ilsong Inst Life Sci, Anyang 431815, Gyeonggi Do, South Korea
Hallym Univ, Grad Sch, Dept Biomed Gerontol, Chunchon, Gangwon Do, South KoreaHallym Univ, Ilsong Inst Life Sci, Anyang 431815, Gyeonggi Do, South Korea
Choi, Eun-Kyoung
[1
,2
]
机构:
[1] Hallym Univ, Ilsong Inst Life Sci, Anyang 431815, Gyeonggi Do, South Korea
[2] Hallym Univ, Grad Sch, Dept Biomed Gerontol, Chunchon, Gangwon Do, South Korea
[3] Hallym Univ, Coll Med, Dept Microbiol, Chunchon, Gangwon Do, South Korea
[4] New York State Inst Basic Res Dev Disabil, Staten Isl, NY 10314 USA
Prion infection leads to neuronal cell death, glial cell activation, and the accumulation of misfolded prion proteins. However, the altered cellular environments in animals with prion diseases are poorly understood. In the central nervous system, cells connect the cytoplasm of adjacent cells via connexin (Cx)-assembled gap junction channels to allow the direct exchange of small molecules, including ions, neurotransmitters, and signaling molecules, which regulate the activities of the connected cells. Here, we investigate the role of Cx43 in the pathogenesis of prion diseases. Upregulated Cx43 expression, which was dependent on c-Jun N-Terminal Kinase (JNK)/c-Jun signaling cascades, was found in prion-affected brain tissues and hippocampal neuronal cells. Scrapie infection-induced Cx43 formed aggregated plaques within the cytoplasmic compartments at the cell-cell interfaces. The ethidium bromide (EtBr) uptake assay and scrape-loading dye transfer assay demonstrated that increased Cx43 has functional consequences for the activity of Cx43 hemichannels. Interestingly, blockade of PrPSc accumulation reduced Cx43 expression through the inhibition of JNK signaling, indicating that PrPSc accumulation may be directly involved in JNK activation-mediated Cx43 upregulation. Overall, our findings describe a scrapie infection-mediated novel regulatory signaling pathway of Cx43 expression and may suggest a role for Cx43 in the pathogenesis of prion diseases.
机构:
Yangtze Univ, Coll Life Sci, Jingzhou, Peoples R ChinaYangtze Univ, Coll Life Sci, Jingzhou, Peoples R China
Li, Yihao
You, Li
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机构:
Chongqing Coll Int Business & Econ, Coll Phys Educ & Hlth, Chongqing, Peoples R ChinaYangtze Univ, Coll Life Sci, Jingzhou, Peoples R China
You, Li
Nepovimova, Eugenie
论文数: 0引用数: 0
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机构:
Univ Hradec Kralove, Fac Sci, Dept Chem, Hradec Kralove, Czech RepublicYangtze Univ, Coll Life Sci, Jingzhou, Peoples R China
Nepovimova, Eugenie
Adam, Vojtech
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机构:
Mendel Univ Brno, Dept Chem & Biochem, Brno, Czech RepublicYangtze Univ, Coll Life Sci, Jingzhou, Peoples R China
Adam, Vojtech
Heger, Zbynek
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机构:
Mendel Univ Brno, Dept Chem & Biochem, Brno, Czech RepublicYangtze Univ, Coll Life Sci, Jingzhou, Peoples R China
Heger, Zbynek
Jomova, Klaudia
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机构:
Constantine Philosopher Univ Nitra, Fac Nat Sci & Informat, Dept Chem, Nitra, SlovakiaYangtze Univ, Coll Life Sci, Jingzhou, Peoples R China
Jomova, Klaudia
Valko, Marian
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机构:
Slovak Univ Technol Bratislava, Fac Chem & Food Technol, Bratislava, SlovakiaYangtze Univ, Coll Life Sci, Jingzhou, Peoples R China
Valko, Marian
Wu, Qinghua
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机构:
Yangtze Univ, Coll Life Sci, Jingzhou, Peoples R China
Univ Hradec Kralove, Fac Sci, Dept Chem, Hradec Kralove, Czech RepublicYangtze Univ, Coll Life Sci, Jingzhou, Peoples R China
Wu, Qinghua
Kuca, Kamil
论文数: 0引用数: 0
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机构:
Univ Hradec Kralove, Fac Sci, Dept Chem, Hradec Kralove, Czech Republic
Univ Granada, Andalusian Res Inst Data Sci & Computat Intelligen, Granada, SpainYangtze Univ, Coll Life Sci, Jingzhou, Peoples R China
机构:
Yangtze Univ, Coll Life Sci, Jingzhou 434025, Peoples R ChinaYangtze Univ, Coll Life Sci, Jingzhou 434025, Peoples R China
Deng, Ying
Adam, Vojtech
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机构:
Mendel Univ Brno, Dept Chem & Biochem, Brno 61300, Czech Republic
Brno Univ Technol, Cent European Inst Technol, Brno 60200, Czech RepublicYangtze Univ, Coll Life Sci, Jingzhou 434025, Peoples R China
Adam, Vojtech
Nepovimova, Eugenie
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hradec Kralove, Fac Sci, Dept Chem, Hradec Kralove 50003, Czech RepublicYangtze Univ, Coll Life Sci, Jingzhou 434025, Peoples R China
Nepovimova, Eugenie
Heger, Zbynek
论文数: 0引用数: 0
h-index: 0
机构:
Mendel Univ Brno, Dept Chem & Biochem, Brno 61300, Czech Republic
Brno Univ Technol, Cent European Inst Technol, Brno 60200, Czech RepublicYangtze Univ, Coll Life Sci, Jingzhou 434025, Peoples R China
Heger, Zbynek
Valko, Marian
论文数: 0引用数: 0
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机构:
Slovak Univ Technol Bratislava, Fac Chem & Food Technol, Bratislava 81237, SlovakiaYangtze Univ, Coll Life Sci, Jingzhou 434025, Peoples R China
Valko, Marian
Wu, Qinghua
论文数: 0引用数: 0
h-index: 0
机构:
Yangtze Univ, Coll Life Sci, Jingzhou 434025, Peoples R China
Univ Hradec Kralove, Fac Sci, Dept Chem, Hradec Kralove 50003, Czech RepublicYangtze Univ, Coll Life Sci, Jingzhou 434025, Peoples R China
Wu, Qinghua
Wei, Wei
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机构:
Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Key Lab Traceabil Agr Genet Modified Organisms, Minist Agr & Rural Affairs, Hangzhou 310021, Peoples R ChinaYangtze Univ, Coll Life Sci, Jingzhou 434025, Peoples R China
Wei, Wei
Kuca, Kamil
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hradec Kralove, Fac Sci, Dept Chem, Hradec Kralove 50003, Czech Republic
Univ Granada, Andalusian Res Inst Data Sci & Computat Intelligen, Granada, SpainYangtze Univ, Coll Life Sci, Jingzhou 434025, Peoples R China
机构:
Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA
Univ Alabama Birmingham, Cardiac Rhythm Management Lab UAB, Birmingham, AL 35294 USA
Univ Alabama Birmingham, Dept Biomed Engn, Birmingham, AL 35294 USAUniv Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA
Yan, Jiajie
Kong, Wei
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Cardiac Rhythm Management Lab UAB, Birmingham, AL 35294 USA
Univ Alabama Birmingham, Dept Biomed Engn, Birmingham, AL 35294 USAUniv Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA
Kong, Wei
Zhang, Qiang
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA
Univ Alabama Birmingham, Cardiac Rhythm Management Lab UAB, Birmingham, AL 35294 USA
Suzhou Municipal Hosp, Div Internal Med, Suzhou, Peoples R ChinaUniv Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA
Zhang, Qiang
Beyer, Eric C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Pediat, Chicago, IL 60637 USAUniv Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA
Beyer, Eric C.
Walcott, Gregory
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机构:
Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA
Univ Alabama Birmingham, Cardiac Rhythm Management Lab UAB, Birmingham, AL 35294 USAUniv Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA
Walcott, Gregory
Fast, Vladimir G.
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机构:
Univ Alabama Birmingham, Cardiac Rhythm Management Lab UAB, Birmingham, AL 35294 USA
Univ Alabama Birmingham, Dept Biomed Engn, Birmingham, AL 35294 USAUniv Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA
Fast, Vladimir G.
Ai, Xun
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h-index: 0
机构:
Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA
Univ Alabama Birmingham, Cardiac Rhythm Management Lab UAB, Birmingham, AL 35294 USA
Univ Alabama Birmingham, Dept Biomed Engn, Birmingham, AL 35294 USA
Univ Alabama Birmingham, UAB Ctr Aging, Birmingham, AL 35294 USAUniv Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA
机构:
Russian Acad Sci, Cardiol Res Inst, Tomsk Natl Res Med Ctr, Tomsk 634012, RussiaRussian Acad Sci, Cardiol Res Inst, Tomsk Natl Res Med Ctr, Tomsk 634012, Russia
Anfinogenova, Nina D.
Quinn, Mark T.
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机构:
Montana State Univ, Dept Microbiol & Immunol, Bozeman, MT 59717 USARussian Acad Sci, Cardiol Res Inst, Tomsk Natl Res Med Ctr, Tomsk 634012, Russia
Quinn, Mark T.
Schepetkin, Igor A.
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机构:
Montana State Univ, Dept Microbiol & Immunol, Bozeman, MT 59717 USA
Tomsk Polytech Univ, Kizhner Res Ctr, Tomsk 634050, RussiaRussian Acad Sci, Cardiol Res Inst, Tomsk Natl Res Med Ctr, Tomsk 634012, Russia
Schepetkin, Igor A.
Atochin, Dmitriy N.
论文数: 0引用数: 0
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机构:
Tomsk Polytech Univ, Kizhner Res Ctr, Tomsk 634050, Russia
Harvard Med Sch, Cardiovasc Res Ctr, Div Cardiol, Massachusetts Gen Hosp, Charlestown, MA 02129 USARussian Acad Sci, Cardiol Res Inst, Tomsk Natl Res Med Ctr, Tomsk 634012, Russia