The 2021 American Society for Clinical Pharmacology and Therapeutics (ASCPT) Annual Meeting, hosted fully online, offered attendees the latest advancements in clinical pharmacology and translational science, sessions presenting ground- breaking research, awardee interviews, poster sessions and more. The ASCPT annual meeting is the most important event for scientists in the clinical pharmacology and translational medicine field, and this year focused on the new challenge "Reimagining the Therapeutic Landscape." The 2021 meeting offered 3 different experiences: the network and community experience, the full conference, and 2 post-meeting workshops. The site allowed for browsing by `Network: Development, Regulatory & Outcomes, quantitative Pharmacology and Translational & Precision Medicine' or by 'Community: Biologics, Drug Utilization & Outcomes, Early Development & Drug, Infectious Diseases, Pharmacog- enomics, Pharmacokinetics and Pharmacodynamics, Special Populations, and Others.' This online experience brought together approximately 1,200 clinical pharmacologists, physicians, pharmacists and other scientists, interested in learning and sharing the latest advancements in drug discovery, drug development, regulation, safety and new drug-related content for human use.