Macrophage function in obesity-induced inflammation and insulin resistance

被引：167
|
作者：
Lauterbach, Mario A. R. [1 ]
Wunderlich, F. Thomas [2 ,3 ]
机构：
[1] Univ Bonn, Univ Hosp, Inst Innate Immun, Sigmund Freud Str 25, D-53127 Bonn, Germany
[2] Univ Cologne, Max Planck Inst Metab Res Cologne, Inst Genet, Cologne Excellence Cluster Cellular Stress Respon, Gleueler Str 50, D-50931 Cologne, Germany
[3] Univ Cologne, Max Planck Inst Metab Res Cologne, Inst Genet, Ctr Endocrinol Diabet & Prevent Med CEDP Cologne, Gleueler Str 50, D-50931 Cologne, Germany
来源：
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2017年 / 469卷 / 3-4期
关键词：
Macrophage; Polarization; Metaflammation; NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; ALTERNATIVELY ACTIVATED MACROPHAGES; ADIPOSE-TISSUE INFLAMMATION; DIET-INDUCED OBESITY; INNATE IMMUNE CELLS; WEIGHT-LOSS; TNF-ALPHA; PROINFLAMMATORY PHENOTYPE; MEDIATED INFLAMMATION;
D O I：
10.1007/s00424-017-1955-5
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The steadily increasing obesity epidemic affects currently 30% of western populations and is causative for numerous disorders. It has been demonstrated that immune cells such as macrophages reside in or infiltrate metabolic organs under obese conditions and cause the so-called low-grade inflammation or metaflammation that impairs insulin action thus leading to the development of insulin resistance. Here, we report on data that specifically address macrophage biology/physiology in obesityinduced inflammation and insulin resistance.
引用
收藏
页码：385 / 396
页数：12
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