An expeditious synthesis of lasofoxifene and nafoxidine via the novel three-component coupling reaction

被引：9

作者：

Sano, Yoshiyuki ^{[1
]}

Nakata, Kenya ^{[1
]}

Otoyama, Takafumi ^{[1
]}

Umeda, Sei ^{[1
]}

Shiina, Isamu ^{[1
]}

机构：

[1] Tokyo Univ Sci, Fac Sci, Dept Appl Chem, Tokyo 1628601, Japan

来源：

CHEMISTRY LETTERS | 2007年 / 36卷 / 01期

关键词：

D O I：

10.1246/cl.2007.40

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The simple and efficient synthesis of lasofoxifene (4), a possible candidate for alleviating osteoporosis, via the novel three-component coupling reaction among 4-pivaloyloxybenzaldehyde (5), cinnamyltrimethylsilane (6), and anisole in the presence of HfCl4 is illustrated. The successive cationic cyclization of the coupling product, olefin formation, and migration of the double-bond are performed to afford the common synthetic intermediate of lasofoxifene (4) and nafoxidine (3) via a very concise procedure.

引用

页码：40 / 41

页数：2

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