Modifier proteins, such as ubiquitin, are passed sequentially between trios of enzymes, like batons in a relay race. Crystal structures suggest the mechanism of transfer between the first two enzymes.
机构:
Sloan Kettering Inst, Struct Biol Program, New York, NY 10065 USASloan Kettering Inst, Struct Biol Program, New York, NY 10065 USA
Lima, Christopher D.
Schulman, Brenda A.
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机构:
St Jude Childrens Res Hosp, Dept Biol Struct, Howard Hughes Med Inst, Memphis, TN 38105 USASloan Kettering Inst, Struct Biol Program, New York, NY 10065 USA