Hedyotis Diffusa Willd. Extracts Inhibit the Proliferation and Migration of Ovarian Cancer Cells by Modulating the AKT/ERK Signaling Pathway

被引：1
|
作者：
Xu, Liwei [1 ]
Guo, Liang [1 ]
Li, Hong [2 ]
Bian, Xiyun [3 ]
机构：
[1] Fifth Cent Hosp Tianjin, Dept Ultrasound, 41 Zhejiang Rd,Binhai New Area, Tianjin 300450, Peoples R China
[2] Fifth Cent Hosp Tianjin, Dept Gynaecol, Tianjin 300450, Peoples R China
[3] Fifth Cent Hosp Tianjin, Cent Lab, Tianjin 300450, Peoples R China
来源：
CURRENT TOPICS IN NUTRACEUTICAL RESEARCH | 2019年 / 17卷 / 04期
关键词：
AKT/ERK pathway; Hedyotis diffusa Willd; Ovarian cancer; ANTICANCER PROPERTIES; METASTASIS; EXPRESSION; APOPTOSIS; AKT;
D O I：
暂无
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Hedyotis diffusa Willd. (HDW) is a traditional Chinese medicine used for the treatment of colorectal cancer. The aim of this study was to investigate the molecular mechanism of inhibitory effects of HDW on the growth of ovarian cancer cells. Treatment of ovarian cancer cells with increasing doses of HDW for 48 or 72h resulted in a significant reduction in the viability and colony formation of cancer cells. In HDW-treated cancer cells, the cell cycle was blocked at the G0/G1 phase and cell apoptosis was 4- to 5-fold higher than that of control group. HDW treatment also markedly inhibited the migration and invasion of ovarian cancer cells. Mechanistically, the phosphorylation levels of AKT and ERK were down-regulated in HDW-treated ovarian cancer cells. Therefore, HDW is likely to become a promising therapeutic agent for ovarian cancer treatment.
引用
收藏
页码：451 / 456
页数：6
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