Mismatch repair proteins and mitotic genome stability

被引：54
|
作者：
Harfe, BD [1 ]
Jinks-Robertson, S [1 ]
机构：
[1] Emory Univ, Dept Biol, Atlanta, GA 30322 USA
来源：
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2000年 / 451卷 / 1-2期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
mismatch repair; mutation; recombination; yeast;
D O I：
10.1016/S0027-5107(00)00047-6
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Mismatch repair (MMR) proteins play a critical role in maintaining the mitotic stability of eukaryotic genomes. MMR proteins repair errors made during DNA replication and in their absence, mutations accumulate at elevated rates. In addition, MMR proteins inhibit recombination between non-identical DNA sequences, and hence prevent genome rearrangements resulting from interactions between repetitive elements. This review provides an overview of the anti-mutator and anti-recombination functions of MMR proteins in the yeast Saccharomyces cerevisiae. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：151 / 167
页数：17
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