Immunomodulatory effects of functionalised chalcones on pro-inflammatory cytokine release from lung epithelial cells

被引：10
|
作者：
Smith, Nicole Maria [1 ]
Soh, Pengkai
Asokananthan, Nithiananthan
Norret, Marck [1 ]
Stewart, Geoffrey A. [1 ]
Raston, Colin Llewellyn [1 ]
机构：
[1] Univ Western Australia, Sch Biomed Biomol & Chem Sci, Ctr Strateg Nanofabricat, Crawley, WA 6009, Australia
来源：
NEW JOURNAL OF CHEMISTRY | 2009年 / 33卷 / 09期
基金：
澳大利亚研究理事会; 英国医学研究理事会;
关键词：
DERIVATIVES;
D O I：
10.1039/b909172f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Chalcones, prepared in high yield in polyethylene glycol, M-w = 300 (PEG300), were screened for inhibition of the thrombin-mediated release of pro-inflammatory interleukin-6 (IL-6) and interleukin-8 (IL-8) from the A549 lung epithelial cell line. Several show significant down-regulation of these pro-inflammatory mediators in a dose-dependant manner with one exhibiting pro-inflammatory properties. Computational studies on selected chalcones revealed a detailed understanding of the structure, electron density and biological activity relationship.
引用
收藏
页码：1869 / 1873
页数：5
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