Retrospective cohort study of clinical characteristics of 2199 hospitalised patients with COVID-19 in New York City

被引：21

作者：

Paranjpe, Ishan ^{[1
]}

Russak, Adam J. ^{[1
,2
]}

De Freitas, Jessica K. ^{[1
,3
]}

Lala, Anuradha ^{[4
,5
]}

Miotto, Riccardo ^{[1
,3
]}

Vaid, Akhil ^{[1
,3
]}

Johnson, Kipp W. ^{[1
,3
]}

Danieletto, Matteo ^{[1
,3
]}

Golden, Eddye ^{[1
,3
]}

Meyer, Dara ^{[3
]}

Singh, Manbir ^{[1
]}

Somani, Sulaiman ^{[1
]}

Kapoor, Arjun ^{[1
]}

O'Hagan, Ross ^{[1
]}

Manna, Sayan ^{[1
]}

Nangia, Udit ^{[1
]}

Jaladanki, Suraj K. ^{[1
]}

O'Reilly, Paul ^{[3
,6
]}

Huckins, Laura M. ^{[3
,6
]}

Glowe, Patricia ^{[1
,3
]}

Kia, Arash ^{[5
,7
]}

Timsina, Prem ^{[5
,7
]}

Freeman, Robert M. ^{[5
,7
]}

Levin, Matthew A. ^{[3
,5
,7
,8
]}

Jhang, Jeffrey ^{[9
]}

Firpo, Adolfo ^{[9
]}

Kovatch, Patricia ^{[10
]}

Finkelstein, Joseph ^{[5
]}

Aberg, Judith A. ^{[11
,12
]}

Bagiella, Emilia ^{[4
,5
]}

Horowitz, Carol R. ^{[5
,12
]}

Murphy, Barbara ^{[12
]}

Fayad, Zahi A. ^{[13
,14
]}

Narula, Jagat ^{[12
,15
]}

Nestler, Eric J. ^{[16
,17
]}

Fuster, V ^{[18
,19
]}

Cordon-Cardo, Carlos ^{[9
]}

Charney, Dennis ^{[20
,21
]}

Reich, David L. ^{[22
]}

Just, Allan ^{[23
,24
]}

Bottinger, Erwin P. ^{[1
]}

Charney, Alexander W. ^{[3
,6
]}

Glicksberg, Benjamin S. ^{[1
,3
,6
]}

Nadkarni, Girish N. ^{[1
,12
,25
]}

机构：

[1] Hasso Plattner Inst Digital Hlth Mt Sinai, New York, NY 10065 USA

[2] Icahn Sch Med Mt Sinai, Dept Internal Med, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA

[4] Zena & Michael A Wiener Cardiovasc Inst, New York, NY USA

[5] Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, New York, NY 10029 USA

[6] Icahn Sch Med Mt Sinai, Pamela Sklar Div Psychiat Genom, New York, NY 10029 USA

[7] Icahn Sch Med Mt Sinai, Inst Healthcare Delivery Sci, New York, NY 10029 USA

[8] Icahn Sch Med Mt Sinai, Icahn Inst Data Sci & Genom Technol, New York, NY 10029 USA

[9] Icahn Sch Med Mt Sinai, Dept Pathol Mol & Cell Based Med, New York, NY 10029 USA

[10] Mt Sinai Hlth Syst, Mt Sinai Data Warehouse, New York, NY USA

[11] Icahn Sch Med Mt Sinai, Div Infect Dis, New York, NY 10029 USA

[12] Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA

[13] Icahn Sch Med Mt Sinai, BioMed Engn & Imaging Inst, New York, NY 10029 USA

[14] Icahn Sch Med Mt Sinai, Dept Biol, New York, NY 10029 USA

[15] Icahn Sch Med Mt Sinai, Dept Cardiol, New York, NY 10029 USA

[16] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA

[17] Icahn Sch Med Mt Sinai, Nash Family Dept Neurosci, New York, NY 10029 USA

[18] Icahn Sch Med Mt Sinai, Dept Med, Div Cardiol, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA

[19] Icahn Sch Med Mt Sinai, Marie Josee & Henry R Kravis Ctr Cardiovasc Hlth, New York, NY 10029 USA

[20] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA

[21] Icahn Sch Med Mt Sinai, Off Dean, New York, NY 10029 USA

[22] Icahn Sch Med Mt Sinai, Dept Anesthesiol Perioperat & Pain Med, New York, NY 10029 USA

[23] Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA

[24] Icahn Sch Med Mt Sinai, Inst Expos Res, New York, NY 10029 USA

[25] Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA

来源：

BMJ OPEN | 2020年 / 10卷 / 11期

基金：

美国国家卫生研究院;

关键词：

infectious diseases; public health; internal medicine; CORONAVIRUS DISEASE 2019;

D O I：

10.1136/bmjopen-2020-040736

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective The COVID-19 pandemic is a global public health crisis, with over 33 million cases and 999 000 deaths worldwide. Data are needed regarding the clinical course of hospitalised patients, particularly in the USA. We aimed to compare clinical characteristic of patients with COVID-19 who had in-hospital mortality with those who were discharged alive. Design Demographic, clinical and outcomes data for patients admitted to five Mount Sinai Health System hospitals with confirmed COVID-19 between 27 February and 2 April 2020 were identified through institutional electronic health records. We performed a retrospective comparative analysis of patients who had in-hospital mortality or were discharged alive. Setting All patients were admitted to the Mount Sinai Health System, a large quaternary care urban hospital system. Participants Participants over the age of 18 years were included. Primary outcomes We investigated in-hospital mortality during the study period. Results A total of 2199 patients with COVID-19 were hospitalised during the study period. As of 2 April, 1121 (51%) patients remained hospitalised, and 1078 (49%) completed their hospital course. Of the latter, the overall mortality was 29%, and 36% required intensive care. The median age was 65 years overall and 75 years in those who died. Pre-existing conditions were present in 65% of those who died and 46% of those discharged. In those who died, the admission median lymphocyte percentage was 11.7%, D-dimer was 2.4 mu g/mL, C reactive protein was 162 mg/L and procalcitonin was 0.44 ng/mL. In those discharged, the admission median lymphocyte percentage was 16.6%, D-dimer was 0.93 mu g/mL, C reactive protein was 79 mg/L and procalcitonin was 0.09 ng/mL. Conclusions In our cohort of hospitalised patients, requirement of intensive care and mortality were high. Patients who died typically had more pre-existing conditions and greater perturbations in inflammatory markers as compared with those who were discharged.

引用

页数：11

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