Concepts from statistical mechanics and ensemble theory are applied to study the characteristic properties of charged particle production in hadron-nucleus collisions at high energy. In the present study we utilize the predictions from different approaches using statistical mechanics. The Tsallis q-statistics is used to study the regularity in multiplicity distributions in hadron-nucleus collisions at high energies as one of the interesting options. Gamma distributions and a possible microcanonical generalization of Tsallis distribution have also been exploited to describe the data.