Pd-Catalyzed Highly Chemo- and Regioselective Hydrocarboxylation of Terminal Alkyl Olefins with Formic Acid

被引：22

作者：

Ren, Wenlong ^{[1
]}

Chu, Jianxiao ^{[1
]}

Sun, Fei ^{[1
]}

Shi, Yian ^{[1
,2
]}

机构：

[1] Changzhou Univ, Inst Nat & Synthet Organ Chem, Changzhou 213164, Peoples R China

[2] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 15期

基金：

中国国家自然科学基金;

关键词：

CARBOXYLIC-ACIDS; ARYL OLEFINS; PALLADIUM; HYDROXYCARBONYLATION; ALKENES; CARBONYLATION; SYSTEM; DERIVATIVES; COMPLEXES; STYRENE;

D O I：

10.1021/acs.orglett.9b02101

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient Pd-catalyzed hydrocarboxylation of alkenes with HCOOH is described. A wide variety of linear carboxylic acids bearing various functional groups can be obtained with excellent chemo- and regioselectivities under mild reaction conditions. The reaction process is operationally simple and requires no handling of toxic CO.

引用

页码：5967 / 5970

页数：4

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