Assessing the transfer of quantitative NIR calibrations from a spectrometer to another one

Many factors account for the optical differences between two near-infrared (NIR) spectrometers of the same make and type. The use of two MR spectrometers may involve different calibrations, that can be transferred only with additional work, like bias adjustments. other sample measurements, model recalculations, conversion of spectral data, etc. In most cases direct transfers of the applications are not possible. In this study the feasibility of a calibration transfer between FOSS/NIRSystems NIR spectrometers was checked. The set of multivariate calibrations for a non-invasive identity testing and a direct determination of the water content in ceftriaxone disodium salt sterile (Rocephin(R)) and in a preparation containing tenoxicam active substance (Tilcotil(R)) filled in vials, was transferred from one spectrometer to another. Separate bias adjustments were calculated for each calibration to fit the spectral data collected on both instruments. These considerations define a practicable procedure to transfer quantitative NIR applications with a reasonable amount of additional work.