Advances in drug delivery system for platinum agents based combination therapy

被引：43
|
作者：
Kang, Xiang [1 ]
Xiao, Hai-Hua [2 ,3 ]
Song, Hai-Qin [4 ,5 ]
Jing, Xia-Bin [2 ]
Yan, Le-San [2 ,3 ]
Qi, Ruo-Gu [2 ,3 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Dept Obstet & Gynecol, Tongji Med Coll, Wuhan 430022, Peoples R China
[2] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[4] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Gen Surg, Sch Med, Shanghai 200025, Peoples R China
[5] Shanghai Minimally Invas Surg Ctr, Shanghai 200025, Peoples R China
来源：
CANCER BIOLOGY & MEDICINE | 2015年 / 12卷 / 04期
关键词：
1ST-LINE TREATMENT; PHASE-I; FLUOROURACIL-LEUCOVORIN; ANTICANCER DRUGS; ETHACRYNIC-ACID; CISPLATIN-DNA; CANCER; CHEMOTHERAPY; OXALIPLATIN; PLATFORM;
D O I：
10.7497/j.issn.2095-3941.2015.0063
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Platinum-based anticancer agents are widely used as first-line drugs in cancer chemotherapy for various solid tumors. However, great side effects and occurrence of resistance remain as the major drawbacks for almost all the platinum drugs developed. To conquer these problems, new strategies should be adopted for platinum drug based chemotherapy. Modern nanotechnology has been widely employed in the delivery of various therapeutics and diagnostic. It provides the possibility of targeted delivery of a certain anticancer drug to the tumor site, which could minimize toxicity and optimize the drug efficacy. Here, in this review, we focused on the recent progress in polymer based drug delivery systems for platinum-based combination therapy.
引用
收藏
页码：362 / 374
页数：13
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