A New Brominated Norsesquiterpene Glycoside From the Rhizomes of Acorus tatarinowii Schott

被引：2

作者：

Hao, Zhi-You ^{[1
,2
]}

Ni, Gang ^{[2
]}

Liang, Dong ^{[2
,3
]}

Liu, Yan-Fei ^{[2
]}

Zhang, Chun-Lei ^{[2
,4
]}

Wang, Yan ^{[2
]}

Zhang, Qing-Jian ^{[2
]}

Chen, Ruo-Yun ^{[2
]}

Yu, De-Quan ^{[2
]}

机构：

[1] Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450046, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing, Peoples R China

[3] Guangxi Ial Univ, Sch Chem & Pharmaceut Sci, Guilin, Peoples R China

[4] China Pharmaceut Univ, Sch Tradit Chinese Pharm, Nanjing, Peoples R China

来源：

NATURAL PRODUCT COMMUNICATIONS | 2021年 / 16卷 / 02期

关键词：

Acorns tatarinowii Schott; acoruside; brominated norsesquiterpene glycoside; structural elucidation; bioactivities; CHEMICAL-CONSTITUENTS; SESQUITERPENOIDS;

D O I：

10.1177/1934578X21992266

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new brominated norsesquiterpene glycoside, acoruside (1), has been isolated from the rhizomes of Acorus tatarinowii Schott, together with 8 known compounds (2-9). Their structures were elucidated mainly based on 1-dimensional (1D) and 2D nuclear magnetic resonance spectra. The absolute configuration of compound 1 was determined by comparing its experimental and calculated electronic circular dichroism spectra. The in vitro tests indicated that at 10 mu M, compounds 2, 3, and 4 aggravated serum deprivation injuries of PC12 cells, compound 2 aggravated rotenone-induced injuries of PC12 cells, and compounds 3 and 4 aggravated the oxygen-glucose deprivation-induced injuries of PC12 cells.

引用

页数：6

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