Analysis of a Mixture Solution Using Silver Nanoparticles Based on Surface-Enhanced Raman Spectroscopy (SERS)

Scopolamine and promethazine can be used as a substitute for heroin. It is relatively fast and simple to use surface enhanced Raman spectroscopy (SERS) for the detection and monitoring of drug usage. Silver nanosol is an enhanced substrate that is commonly used in the SERS technique; the Raman signal of the sample is amplified by the substrate. However, for the detection of mixtures, the competitive adsorption of different components relative to the substrate will result in difficult qualitative identification of spectra. By taking advantage of this defect, the adsorbed components of a mixture were separated from silver nanoparticles by centrifugation, thus changing the mixing ratio of the two components in the mixture. As a result, the proportion of the components with strong adsorption in the mixture is relatively reduced. Thus, the components with weak adsorption can be displayed in the spectrum of the mixed solution.