Objective: Unhealthy weight control behaviors (UWCBs) can lead to numerous health problems. Adolescents who engage in UWCB are more likely to abuse substances than other adolescents. However, few studies have examined the relationship between UWCB and substance use, despite the fact that their co-occurrence can result in greater morbidity and mortality. The aim of this study was to examine the association between UWCB and substance use patterns among Korean adolescents using nationally representative data. Study design: This study involved an analysis of statistical data collected from 27,284 adolescent participants (13-18 years old) in the 2017 Korean Youth Risk Behavior Web-based Survey. Methods: The Chi-squared test and multiple logistic regression analysis were performed to demonstrate the association between substance use patterns (energy drink intake, alcohol use, cigarette smoking, electronic cigarette use, and drug use) and UWCB (one-food diets, fasting, diet pill use, and purging). All statistical analyses were performed to reflect complex sampling weights. Results: More female than male adolescents reported to be engaged in any of the following UWCBs: one-food diets (female: 9.6%, male: 4.8%), fasting (female: 11.6%, male: 7.4%), diet pill use (female: 2.9%, male: 1.5%), and purging (female: 4.1%, male: 2.2%). The prevalence of all UWCBs tended to increase as energy drink intake (P < 0.001), cigarette smoking (P < 0.001), and electronic cigarette use (P < 0.001) increased. Conclusions: Health professionals who work with adolescents need to be aware of the importance of screening for UWCB, including one-food diets, fasting, diet pill use, and purging, especially as a co-occurrence with substance use. (C) 2019 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.