Hyperuricemia is an independent competing risk factor for atrial fibrillation

被引:78
|
作者
Kuwabara, Masanari [1 ,2 ,3 ]
Niwa, Koichiro [1 ]
Nishihara, Shuzo [1 ]
Nishi, Yutaro [1 ]
Takahashi, Osamu [4 ]
Kario, Kazuomi [5 ]
Yamamoto, Kazuhiro [6 ]
Yamashita, Takeshi [7 ]
Hisatome, Ichiro [2 ]
机构
[1] St Lukes Int Hosp, Dept Cardiol, Tokyo, Japan
[2] Tottori Univ, Grad Sch Med Sci, Inst Regenerat Med & Biofunct, Div Regenerat Med & Therapeut, Yonago, Tottori, Japan
[3] Toranomon Gen Hosp, Dept Cardiol, Tokyo, Japan
[4] St Lukes Int Univ, Ctr Clin Epidemiol, Tokyo, Japan
[5] Jichi Med Univ, Sch Med, Dept Med, Div Cardiovasc Med, Shimotsuke, Japan
[6] Tottori Univ, Fac Med, Dept Mol Med & Therapeut, Div Cardiovasc Med Endocrinol & Metab, Yonago, Tottori, Japan
[7] Cardiovasc Inst, Tokyo, Japan
关键词
Atrial fibrillation; Uric acid; Clinical epidemiology; Competing risk factor; SERUM URIC-ACID; CARDIOVASCULAR-DISEASE; ESSENTIAL-HYPERTENSION; ATHEROSCLEROSIS RISK; METABOLIC SYNDROME; STROKE; ASSOCIATION; EVENTS; GOUT; SIZE;
D O I
10.1016/j.ijcard.2016.11.268
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Backgrounds: The relationship between serumuric acid (SUA) and atrial fibrillation (AF) remains unclear because many parameters and diseases influence AF. This study was conducted to clarify the role of hyperuricemia as an independent competing risk factor for AF in an apparently healthy general population. Methods: We retrospectively analyzed the medical records of 90,143 Japanese subjects who underwent annual regular health check-up in St. Luke's International Hospital, Tokyo, between January 2004 and June 2010. Of those subjects, 291 (0.32%) were identified as having AF by 12 leads electrocardiography. First, we analyzed 90,117 subjects to clarify the independent competing risk factors for AF and obtained odds ratios (ORs) by logistic regression analysis. Second, we excluded 40,825 subjects with hypertension, diabetes mellitus, dyslipidemia, chronic kidney disease, and current medication for hyperuricemia and/or gout, andwe analyzed 49,292 subjects. Results: First, AF groups were significantly higher SUA level (OR: 1.35; 95% confidence interval (CI), 1.22-1.50) than non-AF group. OR of hyperuricemia (> 7.0 mg/dL of SUA) for AF was 2.75 (95% CI, 2.10-3.60). Second, after multiple adjustments, higher SUA level (OR: 1.53; 95% CI, 1.21-1.92) was a significantly independent competing risk factor for AF, as well as older age, male sex, higher body mass index, lower FEV1/FVC, and higher hemoglobin. OR of hyperuricemia for AF was 3.19 (95% CI, 1.81-5.62). Conclusions: Hyperuricemia is an independent competing risk factor for AF. Further prospective intervention studies are needed to prove whether lowering SUA level might be important for preventing AF or not. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:137 / 142
页数:6
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