Mechanisms of enveloped RNA virus budding

被引：223
|
作者：
Pornillos, O [1 ]
Garrus, JE [1 ]
Sundquist, WI [1 ]
机构：
[1] Univ Utah, Dept Biochem, Salt Lake City, UT 84132 USA
来源：
TRENDS IN CELL BIOLOGY | 2002年 / 12卷 / 12期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0962-8924(02)02402-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
To spread infection, enveloped viruses must bud from infected host cells. Recent research indicates that HIV and other enveloped RNA viruses bud by appropriating the cellular machinery that is normally used to create vesicles that bud into late endosomal compartments called multivesicular bodies. This new model of virus budding has many potential implications for cell biology and viral pathogenesis.
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页码：569 / 579
页数：11
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