Fertility concerns, preservation strategies and quality of life in young women with breast cancer: Baseline results from an ongoing prospective cohort study in selected European Centers

被引：83

作者：

Ruggeri, M. ^{[1
]}

Pagan, E. ^{[2
]}

Bagnardi, V ^{[2
]}

Bianco, N. ^{[3
]}

Gallerani, E. ^{[4
]}

Buser, K. ^{[5
]}

Giordano, M. ^{[6
]}

Gianni, L. ^{[7
]}

Rabaglio, M. ^{[8
]}

Freschi, A. ^{[9
]}

Cretella, E. ^{[10
]}

Clerico, M. ^{[11
]}

Farolfi, A. ^{[12
]}

Simoncini, E. ^{[13
]}

Ciccarese, M. ^{[14
]}

Rauch, D. ^{[15
]}

Ramello, M. ^{[16
]}

Glaus, A. ^{[17
]}

Berardi, R. ^{[18
]}

Pellanda, A. Franzetti ^{[19
]}

Ribi, K. ^{[20
]}

Gelber, S. ^{[21
]}

Partridge, A. H. ^{[21
,22
]}

Goldhirsch, A. ^{[23
,26
]}

Pagani, O. ^{[24
,25
,27
]}

机构：

[1] Int Breast Canc Study Grp, Program Young Patients, Bern, Switzerland

[2] Univ Milano Bicocca, Dept Stat & Quantitat Methods, Unit Biostat Epidemiol & Publ Hlth, Milan, Italy

[3] European Inst Oncol IRCCS, Div Med Senol, IEO, Milan, Italy

[4] Osped Multimed, Breast Canc Unit, Castellanza, VA, Italy

[5] Lindenhofgrp, Div Oncol Oncocare, Klin Engeried, Bern, Switzerland

[6] Osped St Anna, Med Oncol Unit, Como, Italy

[7] AUSL Romagna, Dept Med Oncol, Osped Infermi, Rimini, Italy

[8] Univ Clin Med Oncol, Inselspital, Bern, Switzerland

[9] CRO, Dept Med Oncol, Aviano, Italy

[10] Azienda Sanitaria DellAlto Adige, Dept Med Oncol, Bolzano, Italy

[11] Osped Inferm Biella, Dept Med Oncol, Biella, Italy

[12] Ist Sci Romagnolo Studio & Cura Tumori IRCCS, Dept Med Oncol, Meldola, Italy

[13] ASST Spedali Civili Brescia, Breast Unit, Brescia, Italy

[14] Vito Fazzi Hosp, UO Oncol Med, Lecce, Italy

[15] Spital STS, Med Oncol, Thun, Switzerland

[16] Azienda ULSS 9, Dept Med Oncol, Treviso, Italy

[17] Tumor & Breast Ctr ZeTup, St Gallen, Switzerland

[18] Univ Politecn Marche, Dept Med Oncol, AOU Osped Riuniti Ancona, Ancona, Italy

[19] Clin Luganese Moncucco, Radiotherapy Serv, Lugano, Switzerland

[20] Int Breast Canc Study Grp, Qual Life Off, Bern, Switzerland

[21] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[22] Harvard Med Sch, Dept Med, Brigham & Womens Hosp, Boston, MA 02115 USA

[23] Int Breast Canc Study Grp, Bern, Switzerland

[24] Inst Oncol, Bellinzona, Switzerland

[25] Breast Unit Southern Switzerland, Bellinzona, Switzerland

[26] MultiMedica, Milan, Italy

[27] Geneva Univ Hosp, Geneva, Switzerland

来源：

BREAST | 2019年 / 47卷

关键词：

Breast cancer; Young women; Fertility concerns; Psychosocial aspects; Quality of life; ADJUVANT HORMONAL-THERAPY; REPRODUCTIVE AGE; ISSUES; SURVIVORS;

D O I：

10.1016/j.breast.2019.07.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objectives: Most research addressing needs and concerns of young patients with breast cancer (<40 years) is retrospective. The HOHO European protocol is a prospective multicenter cohort study of young women with newly diagnosed breast cancer, about fertility, psychosocial and quality of life concerns. Here we report the baseline data and focus on predictors of fertility concerns. Materials and methods: Patient surveys and medical record review were used. The baseline survey included sociodemographic, medical and treatment data as well as questions on fertility concerns and preservation strategies. Subscales from the CAncer Rehabilitation Evaluation System-Short Form (CARES-SF) were administered to measure specific quality of life aspects. Uni- and multivariable modeling were used to investigate predictors of greater fertility concern. Results: Among 297 eligible respondents, 67% discussed fertility issues before starting therapy, 64% were concerned about becoming infertile after treatment, and 15% decided not to follow prescribed therapies. Fifty-four percent of women wished future children before diagnosis; of these, 71% still desired biologic children afterwards. In multivariable analysis, not having children was the only patient characteristic significantly associated with fertility concerns at diagnosis. Twenty-seven percent used fertility preservation strategies. Women who received chemotherapy reported greater physical (p = 0.021) and sexual difficulties (p = 0.039) than women who did not. Women who were married or had a partner reported less psychosocial problems than single women (p = 0.039). Conclusions: Young women with newly diagnosed breast cancer have several concerns, including, but not limited to, fertility. The HOHO European study provides valuable information to develop targeted interventions. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：85 / 92

页数：8

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[J]. JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (11) : 1151 - 1156
[2] Fertility concerns in young women with breast cancer: Results from a prospective cohort study.
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Glaus, A.
Berardi, R.
Franzetti, A.
Ruddy, K. J.
Gelber, S.
Partridge, A. H.
Colleoni, M.
[J]. CANCER RESEARCH, 2017, 77
[7] Preliminary results of an ongoing study on quality of life in women with curable breast cancer
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Pandey, M
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Nair, MK
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Abate, A.
Pastorino, S.
Levaggi, A.
D'Alonzo, A.
Vaglica, M.
Rossi, G.
Blondeaux, E.
Sozzi, F.
Bighin, C.
Miglietta, L.
Pronzato, P.
Del Mastro, L.
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