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- [5] PARASITIC DISEASESLANCET, 1990, 335 (8700): : 1263 - 1266PLAYFAIR, JHLBLACKWELL, JMMILLER, HRP
- [9] Parasitic infectious diseasesEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 193Palacios, FranciscoAlonso, Concepcion
Arginases in parasitic diseases
被引：117
|作者：
Vincendeau, P
[1
]
Gobert, AP
[1
]
Daulouède, S
[1
]
Moynet, D
[1
]
Mossalayi, MD
[1
]
机构：
[1] Univ Bordeaux 2, Equipe Accueil Immunol Mol & Parasitol, F-33076 Bordeaux, France
关键词：
D O I：
10.1016/S1471-4922(02)00010-7
中图分类号：
R38 [医学寄生虫学];
Q [生物科学];
学科分类号：
07 ;
0710 ;
09 ;
100103 ;
摘要：
Parasites have elaborated a variety of strategies for invading hosts and escaping immune responses. This article proposes that a common mechanism whereby different parasites escape nitric oxide (NO) toxicity is the activation of arginase. This leads to a depletion Of L-arginine (substrate of NO synthase, resulting in lower levels of cytotoxic NO) and increased production of polyamines (necessary for parasite growth and differentiation).
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页码：9 / 12
页数：4
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