Automated array technologies for gene expression profiling

Array-based technologies are poised to revolutionize the application of genomic research to drug discovery. These highly parallel techniques are able to simultaneously analyze up to hundreds of thousands of elements, each arrayed al high density across the surface of solid supports. This review provides a summary of some recently established array-based technologies for gene expression profiling. As an example, the authors highlight their experience with OligoFingerprinting - a technology platform that enables the generation of complete profiles of gene expression patterns - and compare it with conventional high-throughput cDNA sequencing.