The negative immunoregulatory effects of serotonin (5-HT) moduline, an endogenous 5-HT1B receptor antagonist with anti-anxiety properties

被引：9

作者：

Maes, M

Kenis, G

Bosmans, E

机构：

[1] Univ Hosp Maastricht, Dept Psychiat, NL-6202 AZ Maastricht, Netherlands

[2] Vanderbilt Univ, Dept Psychiat, Nashville, TN USA

[3] Clin Res Ctr Mental Hlth, Limburg, Belgium

来源：

CYTOKINE | 2002年 / 19卷 / 06期

关键词：

serotonin; moduline; cytokine; interferon; tumor necrosis factor; cAMP;

D O I：

10.1006/cyto.2002.1053

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Serotonin (5-HT) has negative immunoregulatory effects by reducing the interferon-gamma (IFNgamma)/interleukin-10 (IL-10) production ratio by stimulated immune cells. Leukocytes have functional 5-HT1B receptors. 5-HT moduline, an endogenous 5-HT1B receptor antagonist, may antagonize the 5-HT1B agonist-induced proliferation of immune cells. Aims: To examine the effects of 5-HT moduline on the stimulated production of IFNgamma, tumor necrosis factor alpha (TNFalpha) and IL-10. Results: 5-HT moduline, 10(-6) M and 10(-5) M, significantly reduced the production of IFNgamma and the IFNgamma/IL-10 ratio. 5-HT moduline 10(-5)M significantly reduced the production of TNFa. The combination of 5-HT, 15 mug/mL, with 5-HT moduline, 10(-6) M and 10(-5) M, further decreases the IFNgamma/IL-10 production ratio. Interpretation: 5-HT moduline has negative immunoregulatory effects.

引用

页码：308 / 311

页数：4

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