HLA-DQB1*02 allele in children with celiac disease: Potential usefulness for screening strategies

被引：10

作者：

Poddighe, Dimitri ^{[1
,2
]}

Capittini, Cristina ^{[3
]}

Gaviglio, Ivan ^{[2
]}

Brambilla, Ilaria ^{[2
]}

Marseglia, Gian Luigi ^{[2
]}

机构：

[1] Nazarbayev Univ, Sch Med, Dept Med, Nur Sultan City, Astana, Kazakhstan

[2] Univ Pavia, Dept Pediat, Pavia, Italy

[3] Fdn IRCCS Policlin S Matteo, Dept Clin Epidemiol & Biometr, Pavia, Italy

来源：

INTERNATIONAL JOURNAL OF IMMUNOGENETICS | 2019年 / 46卷 / 05期

关键词：

celiac disease; celiac screening; children; HLA-DQB1*02;

D O I：

10.1111/iji.12441

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Through a retrospective analysis of a real-life cohort of children with celiac disease (CD), who underwent HLA-DQ genotyping, we supported our previous findings indicating the presence of HLA-DQB1*02 allele in at least 90%-95% of pediatric patients. In the present study, reporting the HLA-DQ analysis from 184 children (age range: 1-16 years) diagnosed with CD in a single centre, we found that 97.29% of all these CD children (n = 179 out of 184 genotyped patients) resulted to be carriers of at least one copy of HLA-DQB1*02 allele. If a widened screening for CD should result to be appropriate in the pediatric population after further clinical research, this observation might be potentially exploited to consider a two-step screening strategy, starting with the HLA-DQB1*02 targeted analysis followed by the specific serology for CD in these predisposed patients only. However, additional and larger studies are needed to support our findings.

引用

页码：342 / 345

页数：4

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