Interplay between Circadian Clock and Cancer: New Frontiers for Cancer Treatment

被引：270
|
作者：
Sulli, Gabriele [1 ,2 ,3 ]
Lam, Michael Tun Yin [1 ,4 ]
Panda, Satchidananda [1 ]
机构：
[1] Salk Inst Biol Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA
[2] Univ Calif San Diego, Dept Med, Moores Canc Ctr, Div Regenerat Med, La Jolla, CA 92093 USA
[3] Scintillon Inst, San Diego, CA 92121 USA
[4] Univ Calif San Diego, Div Pulm Crit Care & Sleep Med, 9300 Campus Point Dr, La Jolla, CA 92037 USA
来源：
TRENDS IN CANCER | 2019年 / 5卷 / 08期
关键词：
REV-ERB-ALPHA; METASTATIC COLORECTAL-CANCER; DIURNAL CORTISOL RHYTHM; CELL-CYCLE PROGRESSION; PHASE-III TRIAL; FACTOR PERIOD 2; RANDOMIZED MULTICENTER; INNATE IMMUNITY; FOLINIC ACID; GENE PER1;
D O I：
10.1016/j.trecan.2019.07.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Circadian clocks constitute the evolutionary molecular machinery that dictates the temporal regulation of physiology to maintain homeostasis. Disruption of the circadian rhythm plays a key role in tumorigenesis and facilitates the establishment of cancer hallmarks. Conversely, oncogenic processes directly weaken circadian rhythms. Pharmacological modulation of core clock genes is a new approach in cancer therapy. The integration of circadian biology into cancer research offers new options for making cancer treatment more effective, encompassing the prevention, diagnosis, and treatment of this devastating disease. This review highlights the role of the circadian clock in tumorigenesis and cancer hallmarks, and discusses how pharmacological modulation of circadian clock genes can lead to new therapeutic options.
引用
收藏
页码：475 / 494
页数：20
相关论文
共 50 条
  • [1] MYC Ran Up the Clock: The Complex Interplay between MYC and the Molecular Circadian Clock in Cancer
    Burchett, Jamison B.
    Knudsen-Clark, Amelia M.
    Altman, Brian J.
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (14)
  • [2] Interplay between Microbes and the Circadian Clock
    Tognini, Paola
    Murakami, Mari
    Sassone-Corsi, Paolo
    [J]. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2018, 10 (09):
  • [3] The Cancer Clock Is (Not) Ticking: Links between Circadian Rhythms and Cancer
    Morgan, Monica N.
    Dvuchbabny, Sapir
    Martinez, Chloe-Anne
    Kerr, Bernadette
    Cistulli, Peter A.
    Cook, Kristina M.
    [J]. CLOCKS & SLEEP, 2019, 1 (04): : 435 - 458
  • [4] Interplay between circadian clock and viral infection
    Xiaodong Zhuang
    Srinivasa Bhargav Rambhatla
    Alvina G. Lai
    Jane A. McKeating
    [J]. Journal of Molecular Medicine, 2017, 95 : 1283 - 1289
  • [5] Cancer and the Circadian Clock
    Shafi, Ayesha A.
    Knudsen, Karen E.
    [J]. CANCER RESEARCH, 2019, 79 (15) : 3806 - 3814
  • [6] Interplay between circadian clock and viral infection
    Zhuang, Xiaodong
    Rambhatla, Srinivasa Bhargav
    Lai, Alvina G.
    McKeating, Jane A.
    [J]. JOURNAL OF MOLECULAR MEDICINE-JMM, 2017, 95 (12): : 1283 - 1289
  • [7] Circadian coordination: understanding interplay between circadian clock and mitochondria
    Kim, Jeongah
    Sun, Woong
    [J]. ANIMAL CELLS AND SYSTEMS, 2024, 28 (01) : 228 - 236
  • [8] The circadian clock and cancer: links between circadian disruption and disease Pathology
    Fekry, Baharan
    Eckel-Mahan, Kristin
    [J]. JOURNAL OF BIOCHEMISTRY, 2022, : 477 - 486
  • [9] Circadian clock synchrony and chronotherapy opportunities in cancer treatment
    Damato, Anna R.
    Herzog, Erik D.
    [J]. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022, 126 : 27 - 36
  • [10] The tumor circadian clock: a new target for cancer therapy?
    Kiessling, Silke
    Cermakian, Nicolas
    [J]. FUTURE ONCOLOGY, 2017, 13 (29) : 2607 - 2610
12345