The role of protein kinase C (PKC) in the evolution and proliferation of malignant gliomas, and the application of PKC inhibition as a novel approach to anti-glioma therapy

被引：48
|
作者：
Bredel, M
Pollack, IF
机构：
[1] UNIV PITTSBURGH,SCH MED,DEPT NEUROSURG,PITTSBURGH,PA 15261
[2] UNIV PITTSBURGH,INST CANC,BRAIN TUMOR CTR,PITTSBURGH,PA 15261
来源：
ACTA NEUROCHIRURGICA | 1997年 / 139卷 / 11期
关键词：
astrocytoma; cell proliferation; growth factor; inhibition; multidrug resistance; PKC overexpression; protein kinase C; signal transduction; UCN-01;
D O I：
10.1007/BF01411552
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The present article reviews the role of the second messenger enzyme protein kinase C (PKC) in the growth regulation of high grade gliomas, and evaluates the efficacy of therapeutic strategies directed against PKC for blocking the proliferation of these malignancies in in vitro and in vivo models. The translation of such strategies to the treatment of patients with malignant gliomas may provide a novel approach for improving the otherwise grim outlook associated with these neoplasms.
引用
收藏
页码：1000 / 1013
页数：14
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