In vitro and in vivo inhibition of the T315I mutant BCR/ABL kinase.

被引:2
|
作者
Zhu, Hong [1 ]
Hanna, Ehab [1 ]
Lohse, Dan [1 ]
Stoughton, Silva [1 ]
Tam, Betty [1 ]
Barrett, Kathy [1 ]
Noronha, Glenn [1 ]
Dneprovskaia, Elena [1 ]
Cao, Jon [1 ]
Chow, Chun [1 ]
Hwang, Linda [1 ]
Mak, Chiching [1 ]
McPherson, Andy [1 ]
Palanki, Moorthy [1 ]
Pathak, Ved P. [1 ]
Renick, Joe [1 ]
Soil, Richard [1 ]
Zeng, Binqi [1 ]
Hood, John [1 ]
机构
[1] TargeGen Inc, San Diego, CA USA
关键词
D O I
10.1182/blood.V108.11.2182.2182
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
2182
引用
收藏
页码:619A / 619A
页数:1
相关论文
共 50 条
  • [1] Inhibition of the drug-resistant T315I mutant of BCR-Abl
    Zhang, W.
    EJC SUPPLEMENTS, 2006, 4 (12): : 54 - 54
  • [2] Activity of a novel Aurora kinase inhibitor against the T315I mutant form of BCR-ABL:: In vitro and in vivo studies
    Akahane, Daigo
    Tauchi, Tetsuzo
    Okabe, Seiichi
    Nunoda, Kousuke
    Ohyashiki, Kazuma
    CANCER SCIENCE, 2008, 99 (06) : 1251 - 1257
  • [3] Crystal structure of the T315I mutant of abl kinase
    Zhou, Tianjun
    Parillon, Lois
    Li, Feng
    Wang, Yihan
    Keats, Jeff
    Lamore, Sarah
    Xu, Qihong
    Shakespeare, William
    Dalgarno, David
    Zhu, Xiaotian
    CHEMICAL BIOLOGY & DRUG DESIGN, 2007, 70 (03) : 171 - 181
  • [4] Combined Effects of a Pan-ABL1 Kinase Inhibitor, Ponatinib and Dasatinib Against T315I Mutant Forms of BCR-ABL1: In Vitro and In Vivo Studies
    Tauchi, Tetsuzo
    Katagiri, Seiichiro
    Okabe, Seiichi
    Ashihara, Eishi
    Kimura, Shinya
    Maekawa, Taira
    Ohyashiki, Kazuma
    BLOOD, 2011, 118 (21) : 1063 - 1064
  • [5] A Type-II Kinase Inhibitor Capable of Inhibiting the T315I "Gatekeeper" Mutant of Bcr-Abl
    Choi, Hwan Geun
    Ren, Pingda
    Adrian, Francisco
    Sun, Fangxian
    Lee, Hyun Soo
    Wang, Xia
    Ding, Qiang
    Zhang, Guobao
    Xie, Yongping
    Zhang, Jianming
    Liu, Yi
    Tuntland, Tove
    Warmuth, Markus
    Manley, Paul W.
    Mestan, Juergen
    Gray, Nathanael S.
    Sim, Taebo
    JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (15) : 5439 - 5448
  • [6] Emerging strategies for the treatment of mutant Bcr-Abl T315I myeloid leukemia
    Mughal, Tariq I.
    Goldman, John M.
    CLINICAL LYMPHOMA & MYELOMA, 2007, 7 : S81 - S84
  • [7] Role of BCR in the resistance of BCR/ABL harboring the T315I mutation
    Rafiei, A.
    Metodieva, A. T.
    Ottmann, O. G.
    Serve, H.
    Ruthardt, M.
    Mian, A. A.
    ONKOLOGIE, 2011, 34 : 5 - 5
  • [8] Activity of a novel aurora kinase inhibitor, VE-465, against T315I mutant form of BCR-ABL:: In vitro and in vivo studies.
    Tauchi, Tetsuzo
    Akahane, Daigo
    Nunoda, Kosuke
    Okabe, Seiichi
    Ohyashiki, Kazuma
    BLOOD, 2006, 108 (11) : 396A - 397A
  • [9] THE TRANSPHOSPHORYLATION OF BCR IN THE RESISTANCE OF BCR/ABL HARBORING THE T315I MUTATION
    Ruthardt, M.
    Mian, A.
    Metodieva, A.
    Rafiei, A.
    Serve, H.
    Ottmann, O.
    Ruthardt, M.
    HAEMATOLOGICA, 2012, 97 : 2 - 2
  • [10] MK-0457, an Aurora kinase and BCR–ABL inhibitor, is active in patients with BCR–ABL T315I leukemia
    F J Giles
    R T Swords
    A Nagler
    A Hochhaus
    O G Ottmann
    D A Rizzieri
    M Talpaz
    J Clark
    P Watson
    A Xiao
    B Zhao
    D Bergstrom
    P D Le Coutre
    S J Freedman
    J E Cortes
    Leukemia, 2013, 27 : 113 - 117