Anti-Leishmania Effects of Volatile Oils and Their Isolates

被引：10
|
作者：
Fampa, Patricia [1 ,2 ]
Florencio, Melissa [1 ,2 ]
Santana, Raissa Couto [2 ,3 ]
Rosa, Dayana [1 ,2 ]
Soares, Deivid Costa [4 ]
de Matos Guedes, Herbert Leonel [4 ,5 ]
da Silva, Anabela Cordeiro [6 ,7 ,8 ]
Chaves, Douglas Siqueira A. [1 ,2 ]
Pinto-da-Silva, Lucia H. [2 ,3 ]
机构：
[1] Univ Fed Rural Rio De Janeiro, Inst Ciencias Biol & Saude, Dept Ciencias Farmaceut, Seropedica, RJ, Brazil
[2] Univ Fed Rural Rio De Janeiro, Inst Vet, Programa Posgrad Ciencias Vet, Seropedica, RJ, Brazil
[3] Univ Fed Rural Rio de Janeiro, Inst Vet, Dept Microbiol & Imunol Vet, Seropedica, RJ, Brazil
[4] Univ Fed Rio de Janeiro, Inst Microbiol Paulo de Goes, Rio De Janeiro, RJ, Brazil
[5] Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Rio De Janeiro, Brazil
[6] Univ Porto, Fac Farm, Porto, Portugal
[7] Univ Porto, Inst Invest & Inovacao Saude I3S, Porto, Portugal
[8] Inst Biol Mol & Celular, Parasite Dis Grp Res, Porto, Portugal
来源：
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2021年 / 31卷 / 05期
关键词：
Essential oils; Chemotherapy; Natural products; Neglected disease; Phenylpropanoids; Terpenes; CUMINI L. SKEELS; IN-VITRO; CHEMICAL-COMPOSITION; ANTILEISHMANIAL ACTIVITY; PLUCHEA-CAROLINENSIS; LIPPIA; CONSTITUENT; EXTRACTS; EFFICACY; LEAVES;
D O I：
10.1007/s43450-021-00146-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Leishmaniasis consists of a group of neglected diseases, which affect millions of people worldwide. First- and second-line chemotherapies, which present high toxicity and variable efficacy, have been available for decades leading to the appearance of resistance. Globally, volatile oils have received much attention due to their increase use as effective bioactive compounds in folk medicine. They have been employed against Leishmania parasites with a positive impact in the treatment of this neglected disease. In this review, the leishmanicidal activity of volatile oils and their isolates have been described as promising novel candidate molecules for the development of leishmanicidal drugs. The purpose of this review is to critically discuss several works published between 2000 and 2020 that have described the utilization of volatile oils and some of their active principles from diverse plant sources against different species of Leishmania.
引用
收藏
页码：561 / 578
页数：18
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