CD16 aggregation in high affinity conditions by tumor-targeting mAb obinutuzumab promotes a PI3K/mTOR-dependent priming of Natural Killer cells for IFN-gamma production, associated to miR-155 upregulation

被引:0
|
作者
Pighi, C. [1 ]
Capuano, C. [1 ]
Maggio, R. [1 ]
Battella, S. [1 ]
Morrone, S. [1 ]
Palmieri, G. [1 ]
Santoni, A. [2 ]
Klein, C. [3 ]
Galandrini, R. [1 ]
机构
[1] Sapienza Univ Rome, Expt Med, Rome, Italy
[2] Sapienza Univ Rome, Mol Med, Lab Pasteur Italia Fdn Cenci Bolognetti, Rome, Italy
[3] Roche Pharma Res & Early Dev, Roche Innovat Ctr, Zurich, Switzerland
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D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
P366
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收藏
页码:271 / 272
页数:2
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  • [1] CD16 pre-ligation by defucosylated tumor-targeting mAb sensitizes human NK cells to γc cytokine stimulation via PI3K/mTOR axis
    Cristina Capuano
    Chiara Pighi
    Roberta Maggio
    Simone Battella
    Stefania Morrone
    Gabriella Palmieri
    Angela Santoni
    Christian Klein
    Ricciarda Galandrini
    [J]. Cancer Immunology, Immunotherapy, 2020, 69 : 501 - 512
  • [2] CD16 pre-ligation by defucosylated tumor-targeting mAb sensitizes human NK cells to γc cytokine stimulation via PI3K/mTOR axis
    Capuano, Cristina
    Pighi, Chiara
    Maggio, Roberta
    Battella, Simone
    Morrone, Stefania
    Palmieri, Gabriella
    Santoni, Angela
    Klein, Christian
    Galandrini, Ricciarda
    [J]. CANCER IMMUNOLOGY IMMUNOTHERAPY, 2020, 69 (04) : 501 - 512