Chemical Composition, Cytotoxic and Antibacterial Activity of Essential Oil from Aerial Parts of Salvia tebesana Bunge.

In the present study, chemical composition, antibacterial and cytotoxic activities of the essential oil (EO) from aerial parts of Salvia tebesana were investigated. Fifty-five compounds representing 99.7 % of the total oil composition were identified using gas chromatography-mass spectrometry analysis. The EO was predominated by oxygenated sesquiterpenes and the main constituents were E-nerolidol, alpha-eudesmol, trans-caryophyllene, caryophyllene oxide, alpha-pinene, alpha-epi-cadinol, delta-cadinene, and beta-eudesmol, respectively. The cytotoxic effect of the EO on human breast adenocarcinoma, prostate, and melanoma cancer cell lines were examined using AlamarBlue (R) assay. The EO indicated significant cytotoxic activity against the tested cell lines particularly PC-3. Moreover, the antibacterial evaluation of EO against four bacterial strains indicated a potent activity against Gram-positive bacteria particularly Staphylococcus aureus (minimum inhibitory concentration: 1.4 mu g/mL).