The objective is to present a brief overview of peptide and non-peptide factors secreted from adipocytes and to describe some studies on the postulated role of the locally active triad angiotensinogen/angiotensin II/prostacyclin in the development/enlargment of adipose tissue mass and increased blood pressure. In addition to the role of adipose tissue as an endocrine organ, the results emphasize the autocrine/paracrine mechanisms which are postulated to play a role in adipose tissue development and enlargment.
机构:
Beth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol, Boston, MA 02215 USABeth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol, Boston, MA 02215 USA
Kershaw, EE
Flier, JS
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Beth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol, Boston, MA 02215 USABeth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol, Boston, MA 02215 USA
机构:
George Mason Univ, Coll Sci, Ctr Study Chron Metab Dis, Fairfax, VA 22030 USAGeorge Mason Univ, Coll Sci, Ctr Study Chron Metab Dis, Fairfax, VA 22030 USA
McGown, Christine
Birerdinc, Aybike
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George Mason Univ, Coll Sci, Ctr Study Chron Metab Dis, Fairfax, VA 22030 USA
Inova Hlth Syst, Betty & Guy Beatty Ctr Integrated Res, Falls Church, VA 22042 USAGeorge Mason Univ, Coll Sci, Ctr Study Chron Metab Dis, Fairfax, VA 22030 USA
Birerdinc, Aybike
Younossi, Zobair M.
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George Mason Univ, Coll Sci, Ctr Study Chron Metab Dis, Fairfax, VA 22030 USA
Inova Hlth Syst, Betty & Guy Beatty Ctr Integrated Res, Falls Church, VA 22042 USA
Inova Fairfax Hosp, Ctr Liver Dis, Dept Med, Falls Church, VA USAGeorge Mason Univ, Coll Sci, Ctr Study Chron Metab Dis, Fairfax, VA 22030 USA