Determination of Fluoxetine in Human Plasma by Liquid Chromatography-Mass Spectrometry and Its Application

被引：3
|
作者：
Zhou, Neng [1 ]
Chen, Ben-Mei [2 ]
Pan, Tong [3 ]
Liu, Shaogang
机构：
[1] Yulin Teachers Coll, Dept Biol & Chem, Yulin 537000, Peoples R China
[2] Cent S Univ, Analyt Testing Ctr, Xiangya Med Sch, Changsha, Hunan, Peoples R China
[3] Changsha Univ Sci & Technol, Coll Chem & Bioengn, Changsha, Hunan, Peoples R China
来源：
ANALYTICAL LETTERS | 2009年 / 42卷 / 13期
基金：
中国国家自然科学基金;
关键词：
Bioequivalence; clozapine; fluoxetine; LC-ESI-MS; ACTIVE METABOLITE NORFLUOXETINE; SOLID-PHASE EXTRACTION; CAPILLARY-ELECTROPHORESIS; FLUORESCENCE DETECTION; UV DETECTION; HUMAN URINE; SAMPLES; LC; ANTIDEPRESSANTS; PHARMACEUTICALS;
D O I：
10.1080/00032710903082804
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A rapid, simple, and specific liquid chromatography-electrospray ionization-mass spectrometric method has been developed and validated for the determination of fluoxetine in human plasma. The method was validated with a linear range of 0.5-100ng mL-1, and the lowest limits of quantification were 0.5ng mL-1 for fluoxetine. The extraction efficiencies were about 65% and recoveries of method were in the range of 94.0-97.5%. The intraday relative standard deviation (RSD) was less than 11% and interday RSD was within 12%. The method has been successfully applied to the evaluation of pharmacokinetics and bioequivalence of fluoxetine.
引用
收藏
页码：2071 / 2086
页数：16
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