Prevalence of anti-hepatitis A virus antibodies in chidren in Marrakech

Objective: To determine the prevalence of anti-hepatitis A virus (HAV) antibodies among Moroccan children and to examine some of the factors influencing its transmission. Methods: 150 children, aged six months to 14 years, were tested for anti-HAV IgG (indicating past infection). A questionnaire concerning personal and epidemiological data relating to hepatitis A was completed. Results : The overall prevalence of anti-HAV antibodies was 51%. There was no significant difference between male and female children. The proportions of children positive for HAV-IgG varied significantly with age: 70.3% in the 7-14. age range were positive compared with 45.2% aged 6 years and less. Urban inhabitants did not have a higher prevalence than rural residents did. Socioeconomic factors were significantly correlated with the prevalence of anti-HAV-IgG. the father's level of education having the strongest influence. Conclusion : The high overall HAV prevalence in children confirms that Morocco is an intermediately endemic; area for HAV infection. Morocco is entering a transitional phase and the introduction of hepatitis A vaccination in early childhood may reduce the prevalence of this infection and prevent outbreaks. (C) 2009 Elsevier Masson SAS. All rights reserved.