A new synthetic approach and biological evaluation of novel phenothiazines bearing tert-butyl group

被引：7
|
作者：
Trivedi, Amit R. [1 ]
Siddiqui, Arif B. [1 ]
Dodiya, Dipti K. [1 ]
Soalnki, Manish J. [1 ]
Shah, Viresh H. [1 ]
机构：
[1] Saurashtra Univ, Dept Chem, Chem Res Lab, Rajkot 360005, Gujarat, India
来源：
JOURNAL OF SULFUR CHEMISTRY | 2009年 / 30卷 / 06期
关键词：
phenothiazine; p-tert-butyl phenol; 2-amino benzenethiols; oxidative cyclization; antimicrobial activity; SCHIZONTOCIDAL ANTIMALARIAL ACTIVITIES; STRUCTURE-BASED DESIGN; MATRIX METALLOPROTEINASES; INHIBITORS; TUBERCULOSIS; DERIVATIVES;
D O I：
10.1080/17415990903173511
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new and facile synthetic route is proposed for the synthesis of some novel phenothiazines (5a-5g) based on the reaction of 2-amino substituted benzenethiols with p-tert-butyl phenol in good yield. The newly synthesized compounds were characterized by IR, H-1 NMR and mass spectral studies. Their antimicrobial activities against three strains of bacteria: Bacillus subtilis, Bacillus megaterium, Escherichia coli, and two strains of fungi: Aspergillus niger and Aspergillus oryzae, were investigated.
引用
收藏
页码：590 / 595
页数：6
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